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Antiglucocorticoid drugs are a treatment option for Cushing's syndrome, a condition characterized by excessive cortisol production. These medications are primarily used in two scenarios: as preoperative treatment to manage symptoms and reduce surgical risks, and as a long-term solution when surgery has failed or is not feasible.
Cushing's syndrome is a collection of signs and symptoms due to prolonged exposure to glucocorticoids such as cortisol. [4] [9] [10] Signs and symptoms may include high blood pressure, abdominal obesity but with thin arms and legs, reddish stretch marks, a round red face due to facial plethora, [11] a fat lump between the shoulders, weak muscles, weak bones, acne, and fragile skin that heals ...
Metyrapone, sold under the brand name Metopirone, is a medication which is used in the diagnosis of adrenal insufficiency and occasionally in the treatment of Cushing's syndrome (hypercortisolism). It is part of the steroidogenesis inhibitor class of drugs.
"The average diagnostic delay in Cushing's syndrome is approximately two to three years." Patients who take cortisol medication, sometimes to treat asthma and arthritis, are also at increased risk ...
The symptoms of Cushing's disease are similar to those seen in other causes of Cushing's syndrome. [5] Patients with Cushing's disease usually present with one or more signs and symptoms secondary to the presence of excess cortisol or ACTH. [6] Although uncommon, some patients with Cushing's disease have large pituitary tumors (macroadenomas).
Exogenous Cushing syndrome is brought on by taking glucocorticoid medicines, which are typically used to treat inflammatory diseases and pain, according to the Mayo Clinic. This is the version ...
Osilodrostat's safety and effectiveness for treating Cushing's disease among adults was evaluated in a study of 137 adult subjects (about three-quarters women) with a mean age of 41 years. [3] The majority of subjects either had undergone pituitary surgery that did not cure Cushing's disease or were not surgical candidates. [3]
Exogenous Cushing syndrome is brought on by taking glucocorticoid medicines, which are typically used to treat inflammatory diseases and pain, according to the Mayo Clinic. This is the version ...
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