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An operational confounding can occur in both experimental and non-experimental research designs. This type of confounding occurs when a measure designed to assess a particular construct inadvertently measures something else as well. [20] A procedural confounding can occur in a laboratory experiment or a quasi-experiment. This type of confound ...
There are different ways that blocking can be implemented, resulting in different confounding effects. However, the different methods share the same purpose: to control variability introduced by specific factors that could influence the outcome of an experiment.
The stronger the confounding of treatment and covariates, and hence the stronger the bias in the analysis of the naive treatment effect, the better the covariates predict whether a unit is treated or not. By having units with similar propensity scores in both treatment and control, such confounding is reduced.
Adaptive biased-coin randomization methods (of which urn randomization is the most widely known type): In these relatively uncommon methods, the probability of being assigned to a group decreases if the group is overrepresented and increases if the group is underrepresented. [51]
This confounding is depicted in the Figures 1–3 on the right through the bidirected arc between Tutoring Program and GPA. If students are assigned to dormitories at random, the proximity of the student's dorm to the tutoring program is a natural candidate for being an instrumental variable.
An experiment must also control the possible confounding factors—any factors that would mar the accuracy or repeatability of the experiment or the ability to interpret the results. Confounding is commonly eliminated through scientific controls and/or, in randomized experiments, through random assignment.
In other cases, controlling for a non-confounding variable may cause underestimation of the true causal effect of the explanatory variables on an outcome (e.g. when controlling for a mediator or its descendant). [2] [3] Counterfactual reasoning mitigates the influence of confounders without this drawback. [3]
In epidemiology, Mendelian randomization (commonly abbreviated to MR) is a method using measured variation in genes to examine the causal effect of an exposure on an outcome. Under key assumptions (see below), the design reduces both reverse causation and confounding, which often substantially impede or mislead the interpretation of results ...