Search results
Results from the WOW.Com Content Network
Titin A-band has homologs in invertebrates, such as twitchin (unc-22) and projectin, which also contain Ig and FNIII repeats and a protein kinase domain. [27] The gene duplication events took place independently but were from the same ancestral Ig and FNIII domains. It is said that the protein titin was the first to diverge out of the family. [25]
The IUPAC nomenclature for organic chemical compounds is open-ended, giving rise to the 189,819-letter chemical name Methionylthreonyl threonyl . . . iso leucine for the protein also known as titin, which is involved in striated muscle formation. In nature, DNA molecules can be much bigger than protein molecules and therefore potentially be ...
Thick filaments consist primarily of the protein myosin, that is responsible for force generation. It is composed of a globular head with both ATP and actin binding sites, and a long tail involved in its polymerization into myosin filaments. Elastic filaments are made up of a giant protein called titin and hold the thick filaments in place.
The I-type Ig-like domains reside at the C-terminal half, and are most homologous to Ig domains 2-3 of palladin and Ig domains 4-5 of myopalladin and more distantly related to Z-disc Ig domains 7 and 8 of titin. The C-terminal region hosts the binding sites for Z-band proteins, and 2 Ig domains are the site of homodimerization for myotilin. [10]
Alpha-actinin-2 is a 103.8 kDa protein composed of 894 amino acids. [6] [7] Each molecule is rod-shaped (35 nm in length) and it homodimerizes in an anti-parallel fashion.. Each monomer has an N-terminal actin-binding region composed of two calponin homology domains, two C-terminal EF hand domains, and four tandem spectrin-like repeats form the rod domain in the central region of the molecule.
The main proteins involved are myosin, actin, and titin. Myosin and actin are the contractile proteins and titin is an elastic protein. The myofilaments act together in muscle contraction, and in order of size are a thick one of mostly myosin, a thin one of mostly actin, and a very thin one of mostly titin. [1] [2]
84676 433766 Ensembl ENSG00000158022 ENSMUSG00000028834 UniProt Q969Q1 Q38HM4 RefSeq (mRNA) NM_032588 NM_001039048 NM_001369245 RefSeq (protein) NP_115977 n/a Location (UCSC) Chr 1: 26.05 – 26.07 Mb Chr 4: 134.04 – 134.06 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse E3 ubiquitin-protein ligase TRIM63, also known as "MuRF1" (Muscle Ring-Finger Protein-1), is an enzyme that in ...
21393 Ensembl ENSG00000173991 ENSMUSG00000007877 UniProt O15273 O70548 RefSeq (mRNA) NM_003673 NM_011540 RefSeq (protein) NP_003664 NP_003664.1 NP_035670 Location (UCSC) Chr 17: 39.67 – 39.67 Mb Chr 11: 98.27 – 98.28 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Telethonin, also known as Tcap, is a protein that in humans is encoded by the TCAP gene. Telethonin is expressed in ...