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A clinical control group can be a placebo arm or it can involve an old method used to address a clinical outcome when testing a new idea. For example in a study released by the British Medical Journal, in 1995 studying the effects of strict blood pressure control versus more relaxed blood pressure control in diabetic patients, the clinical control group was the diabetic patients that did not ...
The Solomon four-group design is a research method developed by Richard Solomon in 1949. [1] It is sometimes used in social science, psychology and medicine. It can be used if there are concerns that the treatment might be sensitized by the pre-test. [2]
A case series (also known as a clinical series) is a type of medical research study that tracks subjects with a known exposure, such as patients who have received a similar treatment, [1] or examines their medical records for exposure and outcome.
Randomized controlled trial [5]. Blind trial [6]; Non-blind trial [7]; Adaptive clinical trial [8]. Platform Trials; Nonrandomized trial (quasi-experiment) [9]. Interrupted time series design [10] (measures on a sample or a series of samples from the same population are obtained several times before and after a manipulated event or a naturally occurring event) - considered a type of quasi ...
In scientific writing, IMRAD or IMRaD (/ ˈ ɪ m r æ d /) (Introduction, Methods, Results, and Discussion) [1] is a common organizational structure for the format of a document. IMRaD is the most prominent norm for the structure of a scientific journal article of the original research type.
A systematic review is a scholarly synthesis of the evidence on a clearly presented topic using critical methods to identify, define and assess research on the topic. [1] A systematic review extracts and interprets data from published studies on the topic (in the scientific literature), then analyzes, describes, critically appraises and summarizes interpretations into a refined evidence-based ...
"How to design a dose-finding study using the continual reassessment method". BMC Medical Research Methodology. 19 (1): 18. doi: 10.1186/s12874-018-0638-z. PMC 6339349. PMID 30658575. Grayling, Michael John; Wheeler, Graham Mark (2020). "A review of available software for adaptive clinical trial design". Clinical Trials. 17 (3): 323– 331.
In medicine an intention-to-treat (ITT) analysis of the results of a randomized controlled trial is based on the initial treatment assignment and not on the treatment eventually received. ITT analysis is intended to avoid various misleading artifacts that can arise in intervention research such as non-random attrition of participants from the ...