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P2Y 12 is a chemoreceptor for adenosine diphosphate (ADP) [5] [6] that belongs to the G i class of a group of G protein-coupled (GPCR) purinergic receptors. [7] This P2Y receptor family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides .
P2Y 12 structure as generated by PYMOL with color-coded helices. P2Y receptors are membrane proteins belonging to the class A family of G protein-coupled receptors (GPCRs). [5] [6] P2Y receptor proteins display large-scale structural domains typical of GPCRs, consisting of seven hydrophobic transmembrane helices connected by three short extracellular loops and three variably sized ...
Symbol Meaning SI unit of measure magnetic vector potential: tesla meter (T⋅m) : area: square meter (m 2) : amplitude: meter: atomic mass number: unitless acceleration: meter per second squared (m/s 2)
These analogues had very short half-life due to retention of the triphosphate groups and thus needed to be given IV. Modification of these analogues led to the discovery of ticagrelor, a selective and stable non-phosphate P2Y 12 receptor antagonist. [9] Ticagrelor belongs to the class of cyclopentyl-triazolopyrimidine (CPTP). [10]
Microglial processes specifically recognize these purinergic somatic-junctions, and monitor neuronal functions by sensing purine nucleotides via their P2Y12-receptors. In case of neuronal overactivation or injury, microglial processes respond with an increased coverage of neuronal cell bodies, and exert robust neuroprotective effects. [ 38 ]
"High school physics textbooks" (PDF). Reports on high school physics. American Institute of Physics; Zitzewitz, Paul W. (2005). Physics: principles and problems. New York: Glencoe/McGraw-Hill. ISBN 978-0078458132
A branch of physics that studies atoms as isolated systems of electrons and an atomic nucleus. Compare nuclear physics. atomic structure atomic weight (A) The sum total of protons (or electrons) and neutrons within an atom. audio frequency A periodic vibration whose frequency is in the band audible to the average human, the human hearing range.
Continuous charge distribution. The volume charge density ρ is the amount of charge per unit volume (cube), surface charge density σ is amount per unit surface area (circle) with outward unit normal nĚ‚, d is the dipole moment between two point charges, the volume density of these is the polarization density P.