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The 5-nitroimidazole drugs (metronidazole and tinidazole) are the mainstay of treatment for infection with Trichomonas vaginalis. Treatment for both the infected patient and the patient's sexual partner is recommended, even if asymptomatic. Therapy other than 5-nitroimidazole drugs is also an option, but cure rates are much lower. [25]
Tinidazole, sold under the brand name Tindamax among others, is a medication used against protozoan infections.It is widely known throughout Europe and the developing world as a treatment for a variety of anaerobic amoebic and bacterial infections.
Infection is treated and cured with metronidazole [16] or tinidazole. The CDC recommends a one time dose of 2 grams of either metronidazole or tinidazole as the first-line treatment; the alternative treatment recommended is 500 milligrams of metronidazole, twice daily, for seven days if there is failure of the single-dose regimen. [17]
Perhaps the most common example is metronidazole. Other heterocycles such as nitrothiazoles are also used for this purpose. Nitroheterocycles may be reductively activated in hypoxic cells, and then undergo redox recycling or decompose to toxic products. [5] Three nitroimidazole antibiotics: metronidazole, tinidazole, and nimorazole
metronidazole 500–750 mg three times a day for 5–10 days; tinidazole 2g once a day for 3 days is an alternative to metronidazole; Doses for children are calculated by body weight and a pharmacist should be consulted for help.
Treatment is typically with the antibiotics metronidazole or clindamycin. [58] They can be either given by mouth or applied inside the vagina with similar efficacy. [19] [58] Other antibiotics related to metronidazole, including tinidazole and the newer secnidazole, are also approved and used to treat BV.
Antimicrobial spectrum is similar to that of metronidazole and is more well tolerated; [1]: 1368 however there are concerns of lower relative efficacy. [ 3 ] It was first introduced for treating trichomoniasis before being recognized for its broad anti-protozoan and anti-anaerobic-bacterial capacities.
A 14-day course of "quadruple therapy" with a proton pump inhibitor, bismuth, tetracycline, and metronidazole or tinidazole is a more complicated but also more effective regimen. In a 2011 randomized, controlled trial, the per protocol eradication rates were 93% with quadruple therapy and 70% with triple therapy.
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