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2-Methylimidazole (1) may be prepared via the Debus-Radziszewski imidazole synthesis, or from ethylenediamine and acetic acid, followed by treatment with lime, then Raney nickel. 2-Methylimidazole is nitrated to give 2-methyl-4(5)-nitroimidazole (2), which is in turn alkylated with ethylene oxide or 2-chloroethanol to give metronidazole (3 ...
Metronidazole in combination with alcohol causes severe reactions such as vomiting and flushes in many patients. Tetracycline resorption is reduced by dairy products, antacids and other products containing calcium , magnesium , aluminium as well as iron .
Diloxanide is a medication used to treat amoeba infections. [1] In places where infections are not common, it is a second line treatment after paromomycin when a person has no symptoms. [2] For people who are symptomatic, it is used after treatment with metronidazole or tinidazole. [2] It is taken by mouth. [1] Diloxanide generally has mild ...
Secnidazole (trade names Flagentyl, Sindose, Secnil, Solosec) is a nitroimidazole anti-infective.Structurally it actually methyl-metronidazole. Effectiveness in the treatment of dientamoebiasis has been reported. [1]
Perhaps the most common example is metronidazole. Other heterocycles such as nitrothiazoles are also used for this purpose. Nitroheterocycles may be reductively activated in hypoxic cells, and then undergo redox recycling or decompose to toxic products. [5] Three nitroimidazole antibiotics: metronidazole, tinidazole, and nimorazole
However, a 2024 study found that oriental hornets fed sugary solutions containing 1% to 80% ethanol for a week showed no adverse effects on behavior or lifespan. [273] A risk assessment using the margin of exposure (MOE) approach evaluated drugs like alcohol and tobacco. Alcohol had a benchmark dose of 531 mg/kg, while heroin's was 2 mg/kg.
Antibiotics such as metronidazole, tinidazole, cephamandole, latamoxef, cefoperazone, cefmenoxime, and furazolidone, cause a disulfiram-like chemical reaction with alcohol by inhibiting its breakdown by acetaldehyde dehydrogenase, which may result in vomiting, nausea, and shortness of breath. [62]
Vaginal miconazole 20 mg/g - Brazil. Oral treatment: (brand names Daktarin in UK, Fungimin Oral Gel in Bangladesh): [citation needed] In 2010, the US Food and Drug Administration approved Oravig (miconazole) buccal tablets for the local treatment of oropharyngeal candidiasis, more commonly known as thrush, in adults and children age 16 and ...