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Acetophenone is formed as a byproduct of the cumene process, the industrial route for the synthesis of phenol and acetone.In the Hock rearrangement of isopropylbenzene hydroperoxide, migration of a methyl group rather than the phenyl group gives acetophenone and methanol as a result of an alternate rearrangement of the intermediate:
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Phenacyl chloride, also commonly known as chloroacetophenone, is a substituted acetophenone.It is a useful building block in organic chemistry.Apart from that, it has been historically used as a riot control agent, where it is designated CN. [5]
2-Aminoacetophenone, also known as β-ketophenethylamine, α-desmethylcathinone, or phenacylamine, is a substituted phenethylamine derivative. [1] [2] It is the phenethylamine homologue of cathinone (β-ketoamphetamine) and hence is a parent compound of a large number of stimulant and entactogen drugs.
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Piceol is used in the synthesis of several pharmaceutical drugs including octopamine, sotalol, bamethan, and dyclonine. [citation needed] Piceol can be used to make acetaminophen by condensation with hydroxylamine and subsequent Beckmann rearrangement in acid. [4] Anticonvulsants are also possible by Mannich reaction: [5]
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Properties Chemical formula. C 8 H 7 Br O: Molar mass: 199.047 g·mol −1 ... It is prepared by bromination of acetophenone: [2] C 6 H 5 C(O)CH 3 + Br 2 → C 6 H 5 ...