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Fear extinction is the fundamental principle behind exposure therapy, a common treatment for anxiety disorders. In this process, the conditioned fear responses diminish progressively over time, when the previously conditioned stimulus is presented without being paired with the unconditioned stimulus. [20]
The HDACi drug, d-cycloserine, was found to reduce fear in 129S1/SvImJ mice, which are mice that show poor extinction acquisition and recovery of fear-induced suppression of heart-rate variability, enlarged dendritic arbors in basolateral amygdala neurons, and functional abnormalities in cortico-amygdala circuitry that mediates fear extinction ...
Some physiological changes also occurred including the decrease in body weight gain and adrenal hypertrophy observed in animals exposed to stress. Overall, the conditioned fear responses can contribute to behavioral changes in a repeated stress paradigm. This can be extended to correlate to other animals as well but with varying degrees of ...
Pavlovian fear conditioning is a behavioral paradigm in which organisms learn to predict aversive events. [1] It is a form of learning in which an aversive stimulus (e.g. an electrical shock) is associated with a particular neutral context (e.g., a room) or neutral stimulus (e.g., a tone), resulting in the expression of fear responses to the originally neutral stimulus or context.
Neurons in this area aren't fired during the desensitization process despite reducing spontaneous fear responses when artificially fired, suggesting the area stores extinction memories that reduce phobic responses to future stimuli related to the phobia (conditioned), which explains the long-term impact of desensitization. [21]
Exposure therapy is based on the principle of respondent conditioning often termed Pavlovian extinction. [10] The exposure therapist identifies the cognitions, emotions and physiological arousal that accompany a fear-inducing stimulus and then tries to break the pattern of escape that maintains the fear.
Fear is an unpleasant emotion that arises in response to perceived dangers or threats.Fear causes physiological and psychological changes. It may produce behavioral reactions such as mounting an aggressive response or fleeing the threat, commonly known as the fight-or-flight response.
A study done by Loftis and Ross in 1974 looked at the effects of misattribution of arousal upon acquisition and extinction of a conditional emotional response. They conducted two experiments with 89 female undergraduates to show that misattribution procedures can alter physiological response to a conditioned source of a fear or arousal.