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Ibuprofen was derived from propionic acid by the research arm of Boots Group during the 1960s. [73] The name is derived from the 3 functional groups: isobutyl (ibu) propionic acid (pro) phenyl (fen). [74] Its discovery was the result of research during the 1950s and 1960s to find a safer alternative to aspirin.
Ibuprofen, an analgesic and non-steroidal anti-inflammatory drug (NSAID), [1] is sold under many brand-names around the world. The most common are Brufen (its earliest registered trademark), Advil, Motrin, and Nurofen .
The brand first entered the American market in 1984 through Whitehall [3] (itself a division of Wyeth, which was purchased by Pfizer in 2009), [4] the same year ibuprofen gained Food and Drug Administration (FDA) approval for over-the-counter (OTC) sales in the United States (being available via prescription since 1974). [5]
Drug nomenclature is the systematic naming of drugs, especially pharmaceutical drugs.In the majority of circumstances, drugs have 3 types of names: chemical names, the most important of which is the IUPAC name; generic or nonproprietary names, the most important of which are international nonproprietary names (INNs); and trade names, which are brand names. [1]
Ibuprofen became on sale for general pharmacy (over-the-counter) in 1983, as Nurofen. [15] Adams said in 2007 "Getting the drug approved by the two countries with the toughest regulatory authorities – the UK and the US – was a goal I wanted to achieve. For me, that was the most exciting time of all."
Its manufacturing facilities are located in Israel, North America, Europe, Australia, and South America. The company is a member of the Pharmaceutical Research and Manufacturers of America (PhRMA). [4] [5] Teva Pharmaceuticals is the largest generic drug manufacturer in the world. Overall, Teva is the 18th largest pharmaceutical company in the ...
Nurofen is a brand of range of pain-relief medication containing ibuprofen made by the English-Dutch company Reckitt Benckiser. [1] Introduced in 1983, the Nurofen brand was acquired following Reckitt Benckiser's acquisition of Boots healthcare international in 2005 for £1.93 billion, which included Nurofen, Strepsils, and Clearasil. [2]
An advertisement for Boots from 1911. Boots was established in 1849, by John Boot. [7] After his father's death in 1860, Jesse Boot, aged 10, helped his mother run the family's herbal medicine shop in Nottingham, [8] which was incorporated as Boot and Co. Ltd in 1883, becoming Boots Pure Drug Company Ltd in 1888.
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