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A research design typically outlines the theories and models underlying a project; the research question(s) of a project; a strategy for gathering data and information; and a strategy for producing answers from the data. [1] A strong research design yields valid answers to research questions while weak designs yield unreliable, imprecise or ...
The ability to accurately predict target binding sites is a new phenomena, however, which expands on the ability to simply parse a data set of chemical compounds; now due to increasing computational capability, it is possible to inspect the actual geometries of the protein-ligand binding site in vitro.
The DNA template labeled at the 3' or 5' end, depending on the location of the binding site(s). Labels that can be used are: radioactivity and fluorescence.Radioactivity has been traditionally used to label DNA fragments for footprinting analysis, as the method was originally developed from the Maxam-Gilbert chemical sequencing technique.
Non-binding resolutions are usually specific simple or concurrent resolutions that are not passed on to the executive branch to be signed into the law. [2] These resolutions differ from pure concurrent resolutions (that are used for various procedural requests such as adjourning sessions) in that they are designed to express formally, document opinions and not initiate a process.
A design has "binding stopping rules" when the trial must stop when a particular threshold of (either strong or weak) evidence is crossed at a particular interim analysis. Otherwise it has "non-binding stopping rules", in which case other information can be taken into account, for example safety data.
These include repeat sequences in the DNA template, non-specific binding between primer and template, high or low G-C content in the template, or incomplete primer binding, leaving the 5' end of the primer unattached to the template. Non-specific binding of degenerate primers is also common. Manipulation of annealing temperature and magnesium ...
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Thus, protein design algorithms must be able to distinguish between on-target (or positive design) and off-target binding (or negative design). [ 2 ] [ 43 ] One of the most prominent examples of design for specificity is the design of specific bZIP -binding peptides by Amy Keating and coworkers for 19 out of the 20 bZIP families; 8 of these ...