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Grignard reagents or Grignard compounds are chemical compounds with the general formula R−Mg−X, where X is a halogen and R is an organic group, normally an alkyl or aryl. Two typical examples are methylmagnesium chloride Cl−Mg−CH 3 and phenylmagnesium bromide (C 6 H 5)−Mg−Br. They are a subclass of the organomagnesium compounds.
A solution of a carbonyl compound is added to a Grignard reagent. (See gallery) An example of a Grignard reaction (R 2 or R 3 could be hydrogen). The Grignard reaction (French:) is an organometallic chemical reaction in which, according to the classical definition, carbon alkyl, allyl, vinyl, or aryl magnesium halides (Grignard reagent) are added to the carbonyl groups of either an aldehyde or ...
Ethylmagnesium bromide is a Grignard reagent with formula C 2 H 5 ... be used as a strong base to deprotonate various ... wide availability of organolithium reagents.
Phenylmagnesium bromide, with the simplified formula C 6 H 5 MgBr, is a magnesium-containing organometallic compound. It is commercially available as a solution in diethyl ether or tetrahydrofuran (THF). Phenylmagnesium bromide is a Grignard reagent. It is often used as a synthetic equivalent for the phenyl "Ph −" synthon.
n-Propylmagnesium bromide, often referred to as simply propylmagnesium bromide, is an organomagnesium compound with the chemical formula C 3 H 6 MgBr. As the Grignard reagent derived from 1-bromopropane, it is used for the n-propylation of electrophiles in organic synthesis. [1]
The more reactive species, a LiCl-iPrMgCl complex, is called a Turbo-Grignard reagent. These species are related to Turbo-Hauser bases, a family of magnesium amido compounds containing also LiCl. [8] "Turbo-Grignards", as they are often called, are aggregates with the formula [i-PrMgCl·LiCl] 2.
[7] [8] [9] The resulting reagent is then quenched with an electrophile. iPr 2 NMgCl·LiCl and TMPMgCl·LiCl react differently. The TMP-Turbo-Hauser base easily metalates ethyl-3-chlorobenzoate in the C2 position, while the same reaction carried out with the iPr-Turbo-Hauser base resulted in no metalation at all. Instead, an addition ...
Diphenylmethanol may be prepared by a Grignard reaction between phenylmagnesium bromide and benzaldehyde [citation needed]. An alternative method involves reducing benzophenone with sodium borohydride or with zinc dust or with sodium amalgam and water.