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19152 Ensembl ENSG00000277804 ENSG00000196415 ENSMUSG00000057729 UniProt P24158 Q61096 RefSeq (mRNA) NM_002777 NM_011178 RefSeq (protein) NP_002768 NP_035308 Location (UCSC) Chr 19: 0.84 – 0.85 Mb Chr 10: 79.71 – 79.72 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Proteinase 3, also known as PRTN3, is an enzyme that in humans is encoded by the PRTN3 gene. Function PRTN3 is a ...
This pattern results from binding of ANCAs to antigen targets throughout the neutrophil cytoplasm, the most common protein target being proteinase 3 (PR3). For example, PR3 is the most common antigen target of ANCA in patients with granulomatosis with polyangiitis. In active granulomatosis with polyangiitis, c-ANCA is found over 90% of the time ...
Immunofluorescence (IF) on ethanol-fixed neutrophils is used to detect ANCA, although formalin-fixed neutrophils may be used to help differentiate ANCA patterns. ANCA can be divided into four patterns when visualised by IF; cytoplasmic ANCA (c-ANCA), C-ANCA (atypical), perinuclear ANCA (p-ANCA) and atypical ANCA (a-ANCA), also known as x-ANCA. c-ANCA shows cytoplasmic granular fluorescence ...
p-ANCA is associated with several medical conditions: [3] It is fairly specific, but not sensitive for ulcerative colitis, so is not useful as a sole diagnostic test. [4] When measured together with anti-saccharomyces cerevisiae antibodies (ASCA), p-ANCA has been estimated to have a specificity of 97% and a sensitivity of 48% in differentiating patients with ulcerative colitis from normal ...
Granulomatosis with polyangiitis is part of a larger group of vasculitic syndromes called systemic vasculitides or necrotizing vasculopathies, all of which feature an autoimmune attack by an abnormal type of circulating antibody termed ANCAs (antineutrophil cytoplasmic antibodies) against small and medium-size blood vessels.
Humoral immunity is also referred to as antibody-mediated immunity. The study of the molecular and cellular components that form the immune system , including their function and interaction, is the central science of immunology .
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As the gene FYN codes for the enzyme Fyn, FYN-knockout mice display neither excitotoxic events nor dendritic spine shrinkage when injected with Aβ oligomers. [57] In mammals, the full functional significance of PRNP remains unclear, as PRNP deletion has been prophylactically implemented by the cattle industry without apparent harm. [ 56 ]