Search results
Results from the WOW.Com Content Network
An amoeba of the genus Mayorella (Amoebozoa, Discosea). Amoebozoa is a large and diverse group, but certain features are common to many of its members. The amoebozoan cell is typically divided into a granular central mass, called endoplasm, and a clear outer layer, called ectoplasm.
During DNA replication, each strand of DNA is used as a template for the creation of new strands using a partially-conserved mechanism; proper functioning of this process results in two identical, paired chromosomes, often called sisters.
Replication Factories Disentangle Sister Chromatids. The disentanglement is essential for distributing the chromatids into daughter cells after DNA replication. Because sister chromatids after DNA replication hold each other by Cohesin rings, there is the only chance for the disentanglement in DNA replication. Fixing of replication machineries ...
During DNA replication, the replisome will unwind the parental duplex DNA into a two single-stranded DNA template replication fork in a 5' to 3' direction. The leading strand is the template strand that is being replicated in the same direction as the movement of the replication fork.
ATM is a key kinase in the DNA damage checkpoint. Defects in cohesion can increase genome instability, [19] a result consistent with the ties between cohesion and DNA damage pathways. In the bacterium Escherichia coli, repair of mitomycin C-induced DNA damages occurs by a sister chromatid cohesion process involving the RecN protein. [20]
The first member of this family, Mimivirus, was discovered in 2003, [6] and the first complete genome sequence was published in 2004. [7] However, the mimivirus Cafeteria roenbergensis virus [8] was isolated and partially characterized in 1995, [9] although the host was misidentified at the time, and the virus was designated BV-PW1.
At the G1/S checkpoint, p53 acts to ensure that the cell is ready for DNA replication, while at the G2/M checkpoint p53 acts to ensure that the cells have properly duplicated their content before entering mitosis. [40] Specifically, when DNA damage is present, ATM and ATR kinases are activated, activating various checkpoint kinases. [41]
Giant viruses, or nucleocytoplasmic large DNA viruses, frequently infect Amoebozoa and other protists causing amoeba lysis and cell rounding in 12 hours and amoeba population collapse in 55 hours. [3] As such, there is a strong selective pressure on both Amoebozoa and their symbionts to resist these viruses.