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In humans, the MSTN gene is located on the long (q) arm of chromosome 2 at position 32.2. [5] Myostatin (also known as growth differentiation factor 8, abbreviated GDF8) is a protein that in humans is encoded by the MSTN gene. [6] Myostatin is a myokine that is produced and released by myocytes and acts on muscle cells to inhibit muscle growth. [7]
Myostatin, a TGF-beta superfamily member, is a negative regulator of muscle growth. [1] Myostatin binds to ACVR2B and to a lesser extent ACVR2A. In mice that were ACVR2A −/− ( null ) mutants there was an increase in all four muscle groups studied ( pectoralis , triceps , quadriceps , and gastrocnemious / plantaris muscles). [ 1 ]
Myostatin-related muscle hypertrophy is a rare genetic condition characterized by reduced body fat and increased skeletal muscle size. [1] Affected individuals have up to twice the usual amount of muscle mass in their bodies, but increases in muscle strength are not usually congruent. [ 2 ]
An ambitious plan to map all 37 trillion cells in the human body is transforming understanding of how our bodies work, scientists report. The received wisdom said we were built from around 200 ...
The definition and use of the term myokine first occurred in 2003. [5] In 2008, the first myokine, myostatin, was identified. [4] [6] The gp130 receptor cytokine IL-6 (Interleukin 6) was the first myokine found to be secreted into the blood stream in response to muscle contractions.
Due to myostatin's effect as a negative regulator of bone, its inhibition has also been considered for orthopedic diseases such as rheumatoid arthritis. [15] Myostatin inhibitors were generally able to increase lean body mass and reduce body fat in people with sarcopenia, but the extent to which this translated into functional improvements ...
The trunk of the body contains, from superior to inferior, the thoracic region encompassing the chest [1] the mammary region encompassing each breast; the sternal region encompassing the sternum; the abdominal region encompassing the stomach area; the umbilical region is located around the navel; the coxal region encompassing the lateral (side ...
Specialized glands within the human integumentary system # Name Precursor gland derived from [3] Anatomic location 1 Ceruminous gland: Apocrine: Ear canal: 2 Mammary gland: Apocrine: Breast 3 Moll's gland: Apocrine: Eyelid margin 4 Tyson's gland: Sebaceous: Genital skin 5 Meibomian gland: Sebaceous: Tarsal plate: 6 Gland of Zeis: Sebaceous