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Clonidine may improve symptoms of attention deficit hyperactivity disorder in some people but causes many adverse effects and the beneficial effect is modest. [22] In Australia, clonidine is an accepted but not approved use for ADHD by the TGA. [23] Clonidine, along with methylphenidate, has been studied for treatment of ADHD.
Trazodone is usually used at a dosage of 150 to 300 mg/day for the treatment of depression. [ 17 ] [ 13 ] Lower doses have also been used to augment other antidepressants or when initiating therapy. [ 17 ] [ 13 ] Higher doses, up to 600 mg/day, have been used in more severe cases of depression (in hospitalized patients, for example). [ 29 ]
Dogs suffering from separation anxiety are often "owner addicts." While treatment and management options are available for dogs suffering from separation anxiety, there is no instant cure. However, the disorder can dissipate on its own if the trigger stimulus is removed from its environment or the trigger stimulus is desensitized over a period.
A psychiatric assistance dog or psychiatric service dog is a sub-category of assistance dog trained to assist their handler with a psychiatric disability or a mental disability, such as obsessive-compulsive disorder, post-traumatic stress disorder, schizophrenia, depression, anxiety, and bipolar disorder.
Quinidine may interact with chlorpromazine to increase myocardial depression. [5] Likewise, it may also antagonize the effects of clonidine and guanethidine. [5] It also may reduce the seizure threshold and hence a corresponding titration of anticonvulsant treatments should be considered. [5]
It possesses an α 2:α 1 selectivity ratio of 1620:1, making it 8 times more selective for the α 2-adrenergic receptor than the related drug clonidine. [44] [45] Unlike opioids and other sedatives such as propofol, dexmedetomidine is able to achieve its effects without causing respiratory depression.
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