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No antidepressants are FDA approved during pregnancy. [90] Use of antidepressants during pregnancy may result in fetus abnormalities affecting functional development of the brain and behavior. [ 90 ] Studies have shown correlations between pregnant women treated with SNRIs and risk of hypertensive disorders, [ 91 ] preeclampsia, [ 92 ...
Moclobemide is regarded as a generally safe antidepressant and due to its favorable side effect profile, it can be considered a first-line therapeutic antidepressant. [56] The rate of incidence of side effects of moclobemide is low, [ 23 ] with insomnia , headache and dizziness being the most commonly reported side effects in the initial stages ...
This is a complete list of clinically approved prescription antidepressants throughout the world, as well as clinically approved prescription drugs used to augment antidepressants or mood stabilizers, by pharmacological and/or structural classification.
The FDA advises for the risk of birth defects with the use of paroxetine [49] and the MAOI should be avoided. A 2013 systematic review and meta-analysis found that antidepressant use during pregnancy was statistically significantly associated with some pregnancy outcomes, such as gestational age and preterm birth, but not with other outcomes.
Use during pregnancy is of unclear safety. [13] [14] Lurasidone was first approved for medical use in the United States in 2010. [2] In 2013, it was approved in Canada and by the U.S. Food and Drug Administration (FDA) to treat bipolar depression, either as monotherapy or adjunctively with lithium or valproate.
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Investigators conducting clinical trials in the US submitted fraudulent data, and it was never approved in the US. [45]: 21 [46]: 318 Mianserin was one of the first antidepressants to reach the UK market that was less dangerous than the tricyclic antidepressants in overdose; as of 2012 it was not prescribed much in the UK. [47]
This is a list of investigational antidepressants, or drugs that are currently under development for clinical use in the treatment of depression but are not yet approved. Specific indications include major depressive disorder , treatment-resistant depression , dysthymia , bipolar depression , and postpartum depression , among others.
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