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Stress can cause depression and depression-like symptoms through monoaminergic changes in several key brain regions as well as suppression in hippocampal neurogenesis. [116] This leads to alteration in emotion and cognition related brain regions as well as HPA axis dysfunction.
While depression is a complex condition with many factors involved, it is commonly attributed to an imbalance of several key monoamine neurotransmitters, including serotonin, dopamine and norepinephrine. This monoamine hypothesis of depression is popular because of the simplicity of the explanation. [4]
The neurotrophic hypothesis of depression [1] proposes that major depressive disorder (MDD) is caused, at least partly, by impaired neurotrophic support.Neurotrophic factors (also known as neurotrophins) are a family of closely related proteins which regulate the survival, development, and function of neurons in both the central and peripheral nervous systems.
Some people might have a mix of both symptoms of depression and manic symptoms at the same time. ... There may also be imbalances in mood-regulating neurotransmitters (brain chemicals) like ...
“For these individuals, longer daylight hours and intense heat can disrupt their body clocks and cause stress,” Auer explains. “This imbalance can disrupt our energy, sleep, and emotional ...
The exact cause of catatonic depression is not fully understood. [1] However, it is believed to arise from a complex interplay of genetic, biochemical, and environmental factors. Some research suggests that disturbances in neurotransmitters like dopamine and gamma-aminobutyric acid (GABA) may contribute to the development of catatonic symptoms. [2]
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