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Levothyroxine, also known as L-thyroxine, is a synthetic form of the thyroid hormone thyroxine (T 4). [ 5 ] [ 8 ] It is used to treat thyroid hormone deficiency (hypothyroidism), including a severe form known as myxedema coma . [ 5 ]
It is used to treat hypothyroidism, [1] but less preferred than levothyroxine. [1] It is taken by mouth. [1] Maximal effects may take up to three weeks to occur. [1] Side effects may occur from excessive doses. [1] This may include weight loss, fever, headache, anxiety, trouble sleeping, arrhythmias, and heart failure. [1]
Liothyronine may be used when there is an impaired conversion of T 4 to T 3 in peripheral tissues. [1] The dose of liothyronine for hypothyroidism is a lower amount than levothyroxine due it being a higher concentrated synthetic medication. [1]
Levothyroxine, a drug used to treat hypothyroidism, can lead to reduced bone mass and density in older adults with normal thyroid levels, a small cohort study has shown.
Levothyroxine should be used to keep TSH levels within the normal range for that trimester. The first trimester normal range is below 2.5 mIU/L and the second and third trimesters normal range is below 3.0 mIU/L. [ 15 ] [ 43 ] Treatment should be guided by total (rather than free) thyroxine or by the free T 4 index .
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Medical therapy for hyperthyroidism typically involves either titrating the dose of carbimazole until the patient becomes euthyroid or maintaining a high dose of carbimazole to suppress endogenous thyroid production, and then replacing thyroid hormone with levothyroxine ("block and replace").
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