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In chemistry and materials science, impurities are chemical substances inside a confined amount of liquid, gas, or solid. They differ from the chemical composition of the material or compound. [ 1 ] Firstly, a pure chemical should appear in at least one chemical phase and can also be characterized by its phase diagram .
The problem began in 2012, when the process for making tetrazole, a chemical intermediate in the production of various angiotensin II inhibitor medications for hypertension (popularly known by their common drug name suffix "sartan") was changed by generic drug manufacturers in favor of several cheaper and more efficient processes.
In chemistry, chemical purity is the measurement of the amount of impurities found in a sample. Several grades of purity are used by the scientific, pharmaceutical, and industrial communities. Several grades of purity are used by the scientific, pharmaceutical, and industrial communities.
This removes impurities in a substance that an electric current is run through; Sublimation is the process of changing of any substance (usually on heating) from a solid to a gas (or from gas to a solid) without passing through liquid phase. In terms of purification - material is heated, often under vacuum, and the vapors of the material are ...
All listed chemicals [5] as specified in 21 CFR 1310.02 (a) or (b). This includes supplements which contain a listed chemical, regardless of their dosage form or packaging and regardless of whether the chemical mixture, drug product or dietary supplement is exempt from regulatory controls. For each chemical, its illicit manufacturing use is ...
HCPs in biopharmaceutical products pose a potential safety risk to humans by introducing foreign proteins and biomolecules to the human immune system.Since common host cells used to produce biopharmaceutical drugs are E. coli, [8] yeast, [9] mouse myeloma cell line [10] and Chinese hamster ovary (), [11] the resultant HCPs are genetically different to what the human body [12] recognizes.
Pharmaceutical drugs have various known and unknown effects on the environment.. The term environmental persistent pharmaceutical pollutants (EPPP) was first suggested in the nomination in 2010 of pharmaceuticals and environment as an emerging issue in a Strategic Approach to International Chemicals Management [1] by the International Society of Doctors for the Environment (ISDE).
Obvious dangers include containers of chemicals, equipment, and apparatus that could be used to make illegal drugs, drug paraphernalia, and other illegal items. This process does not cleanup or remove chemical spills, stains or residue that could be harmful to inhabitants.