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One of the key pathways in AMPK's regulation of fatty acid oxidation is the phosphorylation and inactivation of acetyl-CoA carboxylase. [28] Acetyl-CoA carboxylase (ACC) converts acetyl-CoA to malonyl-CoA, an inhibitor of carnitine palmitoyltransferase 1 . CPT-1 transports fatty acids into the mitochondria for oxidation. Inactivation of ACC ...
Akt/PKB signalling pathway; AMPK signalling pathway; cAMP-dependent pathway; Eph/ephrin signalling pathway; Hedgehog signalling pathway; Hippo signalling pathway; Insulin signal transduction pathway; JAK-STAT signalling pathway; MAPK/ERK signalling pathway; mTOR signalling pathway; Nodal signalling pathway; Notch signalling pathway; PI3K/AKT ...
AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase ( HMGCR ), key enzymes involved in regulating de novo biosynthesis of fatty acid ...
The pathway is highly regulated by multiple mechanisms, often involving cross-talk with other signaling pathways. Problems with PI3K-Akt pathway regulation can lead to an increase in signaling activity. This has been linked to a range of diseases such as cancer and type 2 diabetes.
AMPK is known to cause GLUT4 deployment to the plasma membrane, resulting in insulin-independent glucose uptake. [122] Some metabolic actions of metformin do appear to occur by AMPK-independent mechanisms, however, AMPK likely has a modest overall effect and its activity is not likely to directly decrease gluconeogenesis in the liver. [123]
AMPK may refer to: AMP-activated protein kinase, an enzyme (acetyl-CoA carboxylase) kinase, an enzyme This page was last edited on 15 May 2022, at ...
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