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Tetrahydrobiopterin (BH 4, THB), also known as sapropterin (), [5] [6] is a cofactor of the three aromatic amino acid hydroxylase enzymes, [7] used in the degradation of amino acid phenylalanine and in the biosynthesis of the neurotransmitters serotonin (5-hydroxytryptamine, 5-HT), melatonin, dopamine, norepinephrine (noradrenaline), epinephrine (adrenaline), and is a cofactor for the ...
Established in 2002, the Canadian International Pharmacy Association ("CIPA") is a Canadian association of licensed pharmacy businesses offering mail order pharmacy services to Canadian and international patients. CIPA members sell pharmaceuticals and maintenance medications to individuals upon receipt of a valid prescription.
The Board of Pharmacy Specialties (BPS) was established in 1976 and is an independent division of the American Pharmacists Association that grants recognition within the United States [1] to appropriate pharmacy practice specialities and establishes standards for certification of pharmacists in 14 specialities. [2]
The Pharmacy Examining Board of Canada (PEBC), established by an Act of Parliament in 1963, is the national certification body for the profession of pharmacy in Canada.It currently assesses the qualifications of 2 pharmacy professional candidates seeking licensure - pharmacists and pharmacy technicians, on behalf the pharmacy regulatory authorities (PRAs) of all provinces except Quebec, and ...
Tetrahydrobiopterin deficiency (THBD, BH 4 D) is a rare metabolic disorder that increases the blood levels of phenylalanine.Phenylalanine is an amino acid obtained normally through the diet, but can be harmful if excess levels build up, causing intellectual disability and other serious health problems.
Ball-and-stick model of the tetrahydroborate anion, [BH 4] −. Borohydride refers to the anion [B H 4] −, which is also called tetrahydridoborate, and its salts. [1] Borohydride or hydroborate is also the term used for compounds containing [BH 4−n X n] −, where n is an integer from 0 to 3, for example cyanoborohydride or cyanotrihydroborate [BH 3 (CN)] − and triethylborohydride or ...
BH4 is the principal active cofactor. BH4 synthesis occurs through two principal pathways; the de novo pathway involves three enzymatic steps and proceeds from GTP, while the salvage pathway converts sepiapterin to BH4 using dihydrofolate reductase. [4] In addition, BH2 is recycled to BH4 by dihydrobiopterin reductase.
Tetrahydroxyborate is an inorganic anion with the chemical formula [BH 4 O 4] − or [B(OH) 4] −.It contributes no colour to tetrahydroxyborate salts. It is found in the mineral hexahydroborite, Ca(B(OH) 4) 2 · 2 H 2 O, originally formulated CaB 2 O 4 · 6 H 2 O. [2]