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Transglutaminase 2 (TG2) is a ubiquitously expressed (intracellular as well as extracellular) protein, with multiple modes of Post-translational regulation, including an allosteric disulfide bond between Cys-370-Cys-371 that renders the enzyme inactive in the extracellular matrix.
The endomysium contains a form of transglutaminase called "tissue transglutaminase" or "tTG" for short, and antibodies that bind to this form of transglutaminase are called endomysial autoantibodies (EmA). [6] The antiendomysial antibody test is a histological assay for patient serum binding to esophageal tissue from primate.
The smallest digest of trypsin and chymotrypsin for the region is a 33mer. [1] This particular region has three tissue transglutaminase sites, two sites that lie within the 14 amino acid insertion, a region of maximal stimulation are found with more than 80% reduction in response for native, un-deaminated, sequence at the position. [26]
The core domain belongs to the papain-like protease superfamily (CA clan) and uses a Cys-His-Asp catalytic triad. [2] Protein 4.2, also referred to as band 4.2, is a catalytically inactive member of the human transglutaminase family that has a Cys to Ala substitution at the catalytic triad. [6]
The IgG antibody is similar to AGA IgA, but is found at higher levels in patients with the IgA-less phenotype. It is also associated with coeliac disease and non-celiac gluten sensitivity. [5] [6] [7] Anti-gliadin antibodies are frequently found with anti-transglutaminase antibodies.
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1 1/4 cup granulated sugar. 1 cup (2 sticks) unsalted butter, at room temperature. 2 large eggs. 2 3/4 cups flour. 1/4 cup instant vanilla pudding mix. 1 teaspoon cream of tartar1 teaspoon baking soda
Not only that though, the helper T cell stimulates B cells to start pumpin’ out IgA antibodies against the gliadin, the transglutaminase enzyme, and endomysial antibodies, or EMAs, which are actually another type of antibody for transglutaminase, but for the transglutaminase found in the endomysium, a layer of connective tissue around muscle ...
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related to: tissue transglutaminase iga 26 eu 10 i 1 4 2