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An agouti dog, also called wolf sable. In dogs, the agouti gene is associated with various coat colors and patterns. [10]The alleles at the A locus are related to the production of agouti-signaling protein (ASIP) and determine whether an animal expresses an agouti appearance and, by controlling the distribution of pigment in individual hairs, what type of agouti.
Agouti-signaling protein is a protein that in humans is encoded by the ASIP gene. [5] [6] It is responsible for the distribution of melanin pigment in mammals.[7] [8] Agouti interacts with the melanocortin 1 receptor to determine whether the melanocyte (pigment cell) produces phaeomelanin (a red to yellow pigment), or eumelanin (a brown to black pigment). [9]
The agouti gene in mice is largely responsible for determining coat colour. The wild-type allele produces a blend of yellow and black pigmentation in each hair of the mouse. This yellow and black blend may be referred to as 'agouti' in colour. [3] One of the mutant alleles of the agouti gene
11604 Ensembl ENSG00000159723 ENSMUSG00000005705 UniProt O00253 P56473 RefSeq (mRNA) NM_001138 NM_001271806 NM_007427 RefSeq (protein) NP_001129 NP_001258735 NP_031453 Location (UCSC) Chr 16: 67.48 – 67.48 Mb Chr 8: 106.29 – 106.36 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Agouti-related protein (AgRP), also called agouti-related peptide, is a neuropeptide produced in the ...
Mouse Genome Informatics (MGI) is a free, online database and bioinformatics resource hosted by The Jackson Laboratory, with funding by the National Human Genome Research Institute (NHGRI), the National Cancer Institute (NCI), and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). [1]
A cat hair showing agouti coloration A domestic rabbit with agouti coloration. Agouti is a type of fur coloration in which each hair displays two or more bands of pigmentation. [1] [2] The overall appearance of agouti fur is usually gray or dull brown, [3] although dull yellow is also possible.
The findings from the epidemiological studies on the non-specific effects of vaccines pose a challenge to the current understanding of vaccines, and how they affect the immune system, and also question whether boys and girls have identical immune systems and should receive the same treatment. The mechanisms for these effects are unclear.
Agouti-signalling protein or ASIP, a circulating hormone encoded by the agouti gene that acts as an antagonist at melanocortin receptors; Agouti-related peptide, a neuropeptide produced in the brain by the AgRP/NPY neuron; Agouti coloration genetics, discussing coat colors created by differences in the agouti gene