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Finally, splice sites (sequences immediately surrounding the exon-intron boundaries) can also be considered as consensus sequences. Thus a consensus sequence is a model for a putative DNA binding site: it is obtained by aligning all known examples of a certain recognition site and defined as the idealized sequence that represents the ...
Circular consensus sequencing (CCS) is a DNA sequencing method that is used in conjunction with single-molecule real-time sequencing to yield highly accurate long-read sequencing datasets with read lengths averaging 15–25 kb with median accuracy greater than 99.9%.
The runt domain of RUNX1 binds to the core consensus sequence TGTGGNNN (where NNN can represent either TTT or TCA). [11] DNA recognition is achieved by loops of the 12-stranded β-barrel and the C-terminus “tail” (residues 170 – 177), which clamp around the sugar phosphate backbone and fits into the major and minor grooves of DNA ...
A common start site is defined within Kozak consensus sequence: (GCC) GCCACCAUGG in vertebrates. The sequence in brackets (GCC) is the motif with unknown biological impact. [5] There are variations within Kozak consensus sequence, such as G or A is observed three nucleotides upstream (at position -3) of AUG.
The sequence at -10 (the -10 element) has the consensus sequence TATAAT. The sequence at -35 (the -35 element) has the consensus sequence TTGACA. The above consensus sequences, while conserved on average, are not found intact in most promoters. On average, only 3 to 4 of the 6 base pairs in each consensus sequence are found in any given promoter.
The TATA box consensus sequence is TATAWAW, where W is either A or T. In molecular biology, the TATA box (also called the Goldberg–Hogness box) [1] is a sequence of DNA found in the core promoter region of genes in archaea and eukaryotes. [2] The bacterial homolog of the TATA box is called the Pribnow box which has a shorter consensus sequence.
It is also commonly called the -10 sequence or element, because it is centered roughly ten base pairs upstream from the site of initiation of transcription. The Pribnow box has a function similar to the TATA box that occurs in promoters in eukaryotes and archaea : it is recognized and bound by a subunit of RNA polymerase during initiation of ...
A contig (from contiguous) is a set of overlapping DNA segments that together represent a consensus region of DNA. [1] In bottom-up sequencing projects, a contig refers to overlapping sequence data (); [2] in top-down sequencing projects, contig refers to the overlapping clones that form a physical map of the genome that is used to guide sequencing and assembly. [3]