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It presents an estimated number of 15 phosphorylation sites (residues 81, 85, 126, 130, 132, 137, 174, 299, 301, 382, 384, 408, 436, 497, 499 and 522) [11] from which 3 -those in bold- have been suggested to be relevant for stimulated-lipolysis through PKA phosphorylation - they correspond respectively to PKA Phosphorylation sites 1, 5 and 6. [12]
Lipolysis can be regulated through cAMP's binding and activation of protein kinase A (PKA). PKA can phosphorylate lipases, perilipin 1A, and CGI-58 to increase the rate of lipolysis. Catecholamines bind to 7TM receptors (G protein-coupled receptors) on the adipocyte cell membrane, which activate adenylate cyclase. This results in increased ...
In cell biology, protein kinase A (PKA) is a family of serine-threonine kinase [1] whose activity is dependent on cellular levels of cyclic AMP (cAMP). PKA is also known as cAMP-dependent protein kinase (EC 2.7.11.11). PKA has several functions in the cell, including regulation of glycogen, sugar, and lipid metabolism.
It is PKA, activated by a hormone-induced signal transduction cascade, that phosphorylates and activates hormone sensitive lipase (HSL), hence the name. In addition to phosphorylating HSL, PKA phosphorylates perilipins on the surface of lipid droplets within adipose cells. This triggers them to "spread out" and allow for HSL to enter the lipid ...
66968 Ensembl ENSG00000214456 ENSMUSG00000011305 UniProt Q00G26 Q8BVZ1 RefSeq (mRNA) NM_001013706 NM_001077348 NM_025874 RefSeq (protein) NP_001013728 NP_001070816 NP_080150 Location (UCSC) Chr 19: 4.52 – 4.54 Mb Chr 17: 56.42 – 56.42 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Perilipin 5, also known as Oxpatperilipin 5 or PLIN5, is a protein that belongs to perilipin family ...
57104 66853 Ensembl ENSG00000177666 ENSMUSG00000025509 UniProt Q96AD5 Q8BJ56 RefSeq (mRNA) NM_020376 NM_001163689 NM_025802 RefSeq (protein) NP_065109 NP_001157161 NP_080078 Location (UCSC) Chr 11: 0.82 – 0.83 Mb Chr 7: 141.04 – 141.04 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Adipose triglyceride lipase, also known as patatin-like phospholipase domain-containing protein 2 ...
In computational biology, protein pK a calculations are used to estimate the pK a values of amino acids as they exist within proteins.These calculations complement the pK a values reported for amino acids in their free state, and are used frequently within the fields of molecular modeling, structural bioinformatics, and computational biology.
The enzyme apparently manipulates the pKa to facilitate the deprotonation of bicarbonate. The pKa of bicarbonate is decreased by its interaction with positively charged side chains of Arg338 and Arg292. Furthermore, Glu296 interacts with the side chain of Glu211, an interaction that has been shown to cause an increase in the apparent pKa.