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Heterologous desensitization (also known as cross-desensitization) is the term for the unresponsiveness of cells to one or more agonists to which they are normally ...
In medicine, desensitization is a method to reduce or eliminate an organism's negative reaction to a substance or stimulus. In pharmacology , drug desensitization refers to two related concepts. First, desensitization may be equivalent to drug tolerance and refers to subjects' reactions (positive or negative) to a drug reducing following its ...
While heterologous desensitization occurs rapidly at low agonist concentrations, homologous desensitization shows a dose dependent response and usually begins at significantly higher concentrations. [3] [4] Homologous desensitization serves as a mechanism for tachyphylaxis and helps organisms to maintain homeostasis.
This is an example of a locally acting (negative feedback) mechanism. An example of upregulation is the response of liver cells exposed to such xenobiotic molecules as dioxin . In this situation, the cells increase their production of cytochrome P450 enzymes , which in turn increases degradation of these dioxin molecules.
Today's Connections Game Answers for Saturday, January 25, 2025: 1. SCHOOL PERIODS: CLASS, HOMEROOM, LUNCH, RECESS 2. FEATURES OF A SKI RESORT: LIFT, LODGE, MOGUL ...
The dress code for the 2025 Met Gala has been announced, and this year menswear is taking center stage.. In conjunction with the upcoming exhibit at the Metropolitan Museum of Art's Costume ...
These latter two mechanisms allow for desensitization of one GPCR due to the activities of others, or heterologous desensitization. GRKs may also have GAP domains and so may contribute to inactivation through non-kinase mechanisms as well. A combination of these mechanisms may also occur.
Singapore has passed a law designed to protect against foreign interference in its race-based clans and business associations, as the government looks to limit outsiders from undermining racial ...