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Epidermal growth factor (EGF) is a protein that stimulates cell growth and differentiation by binding to its receptor, EGFR. Human EGF is 6-k Da [ 5 ] and has 53 amino acid residues and three intramolecular disulfide bonds .
As a recombinant form of EGF, nepidermin is an agonist of the epidermal growth factor receptor (EGFR), and is the first EGFR agonist to be marketed. [ 3 ] [ 4 ] It was developed by Cuban Center for Genetic Engineering and Biotechnology (CIBG), and has been marketed by Heber Biotech as an intralesional injection for diabetic foot ulcer under the ...
Quote: "Similarities exist between the aging skin and wound healing, and mostly they involve the same oxidation and repair mechanisms..." 'The use of epidermal growth factor in dermatological practice'[literature review] Sun Hye Shin, Young Gue Koh, Woo Geon Lee, Joon Seok, Kui Young Park. International Wound Journal. 2023 Aug;20(6):2414-2423.
A growth factor is a naturally occurring substance capable of stimulating cell proliferation, wound healing, and occasionally cellular differentiation. [1] Usually it is a secreted protein or a steroid hormone .
The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor for members of the epidermal growth factor family (EGF family) of extracellular protein ligands. [5]
Cetuximab, sold under the brand name Erbitux, is an epidermal growth factor receptor (EGFR) inhibitor medication used for the treatment of metastatic colorectal cancer and head and neck cancer. [2] Cetuximab is a chimeric (mouse/human) monoclonal antibody given by intravenous infusion .
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