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Efficient and safe delivery of saRNA into target cells remains a critical hurdle, with lipid nanoparticles (LNPs) and other delivery systems currently being optimized to address this issue. Ensuring the long-term safety of saRNA is also important, and ongoing research is focused on minimizing potential side effects and immune reactions.
Urea, also known as carbamide-containing cream, [clarification needed] is used as a medication and applied to the skin to treat dryness and itching such as may occur in psoriasis, dermatitis, or ichthyosis. [1] [2] [3] It may also be used to soften nails. [3] In adults side effects are generally few. [4] It may occasionally cause skin ...
Lotion and shampoo at the Banff Centre. Lotion is a low-viscosity topical preparation intended for application to the skin. By contrast, creams and gels have higher viscosity, typically due to lower water content. [1] [2] Lotions are applied to external skin with bare hands, a brush, a clean cloth, or cotton wool.
A 2002 review found "some reports indicate that inappropriate BC (barrier cream) application might induce a deleterious rather than a beneficial effect." [ 6 ] Skin that has been moisturized by barrier cream may be more susceptible to irritation by sodium lauryl sulfate , which can permeate hydrated skin more easily due to its hydrophilia . [ 5 ]
To identify an saRNA that can activate a gene of interest, several saRNAs need to be designed within a 1- to 2-kbp promoter region by following a set of rules [3] [4] and tested in cultured cells. In some reports, saRNAs are designed in such a way to target non-coding transcripts that overlap the promoter sequence of a protein coding gene.
Pramocaine (INN and BAN, also known as pramoxine or pramoxine HCl) is a topical anesthetic discovered at Abbott Laboratories in 1953 [1] and used as an antipruritic.During research and development, pramocaine hydrochloride stood out among a series of alkoxy aryl alkamine ethers as an especially good topical local anesthetic agent. [1]
Sunscreen, also known as sunblock, [a] sun lotion or sun cream, is a photoprotective topical product for the skin that helps protect against sunburn and prevent skin cancer. Sunscreens come as lotions , sprays, gels, foams (such as an expanded foam lotion or whipped lotion [ 4 ] ), sticks, powders and other topical products.
[15] [16] Based on the study, the systematic review concluded that selenium disulfide may be effective in the treatment of dandruff but that the available evidence is limited and overall evidence quality is low. [15] It also found that while selenium disulfide has infrequent side effects, it seems to have more side effects than ketoconazole ...