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An organ-on-a-chip (OOC) is a multi-channel 3-D microfluidic cell culture, integrated circuit (chip) that simulates the activities, mechanics and physiological response of an entire organ or an organ system.
Luton, Bedfordshire, United Kingdom, Dec. 04, 2024 (GLOBE NEWSWIRE) -- Organ-on-chip technology (オルガンオンチップ市場), which uses microfluidic devices to mimic the functions of human organs, is poised to transform the pharmaceutical and healthcare industries by providing more accurate and cost-effective platforms for research and development.
Schematic of the Emulate liver-chip [4] Emulate's Organs-on-Chips technology has been used to recreate the function of a variety of different organs, including the liver, intestine, brain, kidney, and lung. [5] The company's Organ-Chips are about the size of a AA battery and feature two fluidic channels that create the flow of blood and other ...
Following the lung-on-a-chip, the team built a kidney-on-a-chip and an intestine-on-a-chip. [14] In 2014, Emulate spun out to make organ chips commercially available for other scientists to use for disease modeling and drug testing, [15] [16] [17] including those at Johnson & Johnson, Merck, Takeda, Roche, and Cedars-Sinai Medical Center. [18]
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Organ printing technology can also be combined with microfluidic technology to develop organs-on-chips. [29] These organs-on-chips have the potential to be used for disease models, aiding in drug discovery, and performing high-throughput assays. [29] Organ-on-chips work by providing a 3D model that imitates the natural extracellular matrix ...
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Schematic drawing of a lung-on-a-chip. The membrane in the middle can be stretched by vacuum in the two side chambers. Lung-on-a-chip (LoC), also known as Lung Chips, are micro- and millifluidic organ-on-a-chip devices designed to replicate the structure and function of the human lung, mimicking the breathing motions and fluid dynamics that occur during inhalation and exhalation. [1]