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Pethidine is the most widely used opioid in labour and delivery. [16] It has fallen out of favour in some countries, such as the United States, in favour of other opioids, due to its potential drug interactions, especially with serotonergics, and its neurotoxic metabolite, norpethidine . [ 10 ]
The Philippines' Bureau of Agriculture and Fisheries Product Standards (Filipino: Kawanihan ng mga Pamantayan sa Produktong Pansaka at Pampangisdaan, abbreviated as BAFS), is an agency of the Philippine government under the Department of Agriculture responsible for setting and implementing standards for fresh primary and secondary processed agricultural and fishery products.
It was created on May 24, 1978, through Presidential Decree 1380 to spearhead the development of the country's postharvest industry. As a subsidiary of the National Grains Authority (NGA) in 1980, BPRE's powers and functions were expanded through LOI 1142 to include other agricultural commodities in line with the conversion of NGA to the ...
Hydroxypethidine (Bemidone) is an opioid analgesic that is an analogue of the more commonly used pethidine (meperidine). Hydroxypethidine is slightly more potent than meperidine as an analgesic, 1.5x meperidine in potency, [2] and it also has NMDA antagonist properties like its close relative ketobemidone.
Agriculture in the Philippines is a major sector of the economy, ranking third among the sectors in 2022 behind only Services and Industry. Its outputs include staples like rice and corn, but also export crops such as coffee , cavendish banana , pineapple and pineapple products, coconut , sugar , and mango . [ 1 ]
Pethidinic acid (meperidinic acid, pethidine intermediate C) is a 4-phenyl piperidine derivative that is both a metabolite of and a precursor to pethidine (meperidine). [2] [3] It is scheduled by UN Single Convention on Narcotic Drugs. It is a Schedule II Narcotic controlled substance in the United States and has an ACSCN of 9234.
Norpethidine (normeperidine, pethidine intermediate B) is a 4-phenylpiperidine derivative that is both a precursor to, and the toxic metabolite of, pethidine (meperidine). It is scheduled by UN Single Convention on Narcotic Drugs. It is a Schedule II Narcotic controlled substance in the United States and has an ACSCN of 9233.
Its potency range is due to method of ingestion. figure 20–80 times as potent as pethidine as an analgesic. The greatly increased potency essentially eliminates the toxic effects of norpethidine accumulation which are seen when pethidine is administered in high doses or for long periods of time. [4]