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The enzyme involved in making 1-deoxy-d-xylulose 5-phosphate (DXP) is DXP synthase. [2] The mechanism follows a catalysis of decarboxylative condensation of pyruvate and d-glyceraldehyde 3-phosphate to produce DXP. [2] [3] In addition, the molecule is involved in making thiamine (vitamin B 1) and pyridoxol (vitamin B 6). [2]
In enzymology, a 1-deoxy-d-xylulose-5-phosphate synthase (EC 2.2.1.7) is an enzyme in the non-mevalonate pathway that catalyzes the chemical reaction pyruvate + d -glyceraldehyde 3-phosphate ⇌ {\displaystyle \rightleftharpoons } 1-deoxy- d -xylulose 5-phosphate + CO 2
D-Xylulose 5-phosphate (D-xylulose-5-P) is an intermediate in the pentose phosphate pathway. It is a ketose sugar formed from ribulose-5-phosphate by ribulose-5-phosphate epimerase. In the non-oxidative branch of the pentose phosphate pathway, xylulose-5-phosphate acts as a donor of two-carbon ketone groups in transketolase reactions. [2]
DXP reductoisomerase (also known as: DXR, DOXP reductoisomerase, IspC, MEP synthase), is a key enzyme in the MEP pathway. It can be inhibited by the natural product fosmidomycin , which is under study as a starting point to develop a candidate antibacterial or antimalarial drug.
DXP may refer to: 1-Deoxy-D-xylulose 5-phosphate, chemical compound; 1-deoxy-D-xylulose-5-phosphate synthase (also DXP-synthase), an enzyme; Deep eXecution Processor, a class of processor made by British multinational fabless semiconductor company Icera; Domino's DXP, custom third-generation Chevrolet Sparks commissioned by Domino's Pizza
In Arabidopsis thaliana 1-deoxy-D-xylulose 5-phosphate reductoisomerase is the first committed enzyme of the MEP pathway for isoprenoid precursor biosynthesis. The enzyme requires Mn 2+, Co 2+ or Mg 2+ for activity, with Mn 2+ being most effective.
During the oxidative phase of the pentose phosphate pathway, it is formed from 6-phosphogluconolactone by 6-phosphogluconolactonase, and in turn, it is converted to ribulose 5-phosphate by phosphogluconate dehydrogenase, in an oxidative decarboxylation which also produces NADPH.
Deoxyadenosine monophosphate (dAMP), also known as deoxyadenylic acid or deoxyadenylate in its conjugate acid and conjugate base forms, respectively, is a derivative of the common nucleotide AMP, or adenosine monophosphate, in which the -OH group on the 2' carbon on the nucleotide's pentose has been reduced to just a hydrogen atom (hence the "deoxy-" part of the name).