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Haptoglobin (abbreviated as Hp) is the protein that in humans is encoded by the HP gene. [5][6] In blood plasma, haptoglobin binds with high affinity to free hemoglobin [7] released from erythrocytes, and thereby inhibits its deleterious oxidative activity. Compared to Hp, hemopexin binds to free heme. [8]
Hemoglobinemia (or haemoglobinaemia) is a medical condition in which there is an excess of hemoglobin in the blood plasma. This is an effect of intravascular hemolysis, in which hemoglobin separates from red blood cells, a form of anemia. Hemoglobinemia can be caused by intrinsic or extrinsic factors. When hemoglobinemia is internally caused ...
Hemolytic anemia accounts for 5% of all existing anemias.[2] It has numerous possible consequences, ranging from general symptoms to life-threatening systemic effects.[2] The general classification of hemolytic anemia is either intrinsic or extrinsic.[3] Treatment depends on the type and cause of the hemolytic anemia.
However, during hyper-hemolytic conditions or with chronic hemolysis, haptoglobin is depleted so the remaining free hemoglobin readily distribute to tissues where it might be exposed to oxidative conditions, [2] thus some of the ferrous heme (FeII), the oxygen-binding component of hemoglobin, of the free hemoglobin are oxidized and becoming met ...
Danicopan, sold under the brand name Voydeya, is a medication used for the treatment of paroxysmal nocturnal hemoglobinuria. It is a complement inhibitor which reversibly binds to factor D to prevent alternative pathway-mediated hemolysis and deposition of complement C3 proteins on red blood cells. The most common side effects include fever, headache, increased levels of liver enzymes (a sign ...
Often girls and young women don’t realize that what they’re feeling is a sign of an iron deficiency because the symptoms can be subtle or can be dismissed as being due to other problems like ...
Autoimmune hemolytic anemia (AIHA) is an autoimmune disorder which occurs when antibodies directed against the person's own red blood cells (RBCs) cause them to burst (lyse), leading to an insufficient number of oxygen-carrying red blood cells in circulation (anemia). The lifetime of the RBCs is reduced from the normal 100–120 days to just a ...
HELLP syndrome is a complication of pregnancy; the acronym stands for hemolysis, elevated liver enzymes, and low platelet count. [ 1 ] It usually begins during the last three months of pregnancy or shortly after childbirth. [ 1 ] Symptoms may include feeling tired, retaining fluid, headache, nausea, upper right abdominal pain, blurry vision ...