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Iron overload (also known as haemochromatosis or hemochromatosis) is the abnormal and increased accumulation of total iron in the body, leading to organ damage. [1] The primary mechanism of organ damage is oxidative stress, as elevated intracellular iron levels increase free radical formation via the Fenton reaction.
It is unlikely to get iron poisoning from diet alone with iron supplements being the cause of overdose. The amount of elemental iron in an iron supplement can be calculate based on the percentage it constitutes for per tablet. For example, a 300 mg tablet of ferrous fumarate will contain 100 mg of elemental iron or 33%.
The most common type is iron-deficiency anemia, in which a lack of iron leads to a reduction in the number of red blood cells or hemoglobin. This can impair oxygen transport throughout the body.
Red blood cells normally survive an average of about 120 days, becoming damaged (their oxygen-carrying capacity becomes compromised) as they age.
[4] [12] Iron chelation therapy is used to treat iron overload and common iron chelators used are deferoxamine, deferiprone and deferasirox. [9] [13] Due to the complications of transfusions dependency, it may be more ideal to directly treat the cause of anemia if possible. However, this might not be suitable for all patients, and some may ...
Causes include excessive alcohol use (the most common cause of sideroblastic anemia), pyridoxine deficiency (vitamin B 6 is the cofactor in the first step of heme synthesis [8]), lead poisoning [9] and copper deficiency. [10] Excess zinc [11] can indirectly
Nutritional causes are vitamin and mineral deficiencies and non-nutritional causes include infections. The number one cause of this type of anemia, however, is iron deficiency. [12] An insufficient intake of iron, Vitamin B12, and folic acid impairs the bone marrow function. The lack of iron within a person's body can also stem from ulcer bacteria.
Iron deficiency can cause a slew of ... the iron fish practice was only effective in the short term against iron deficiency anemia, ... a.k.a. iron overload, can occur for genetic reasons or ...
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