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A more focused functional genomics approach might test the function of all variants of one gene and quantify the effects of mutants by using sequencing as a readout of activity. Together these measurement modalities endeavor to quantitate the various biological processes and improve our understanding of gene and protein functions and interactions.
The key issue then is the translation of these newly identified genetic variants (from Copy Number Variant studies, candidate gene sequencing and high throughput sequencing technologies) into an intervention for patients with neurogenomic disorders. One aspect will be if the neurological disorder are medically actionable (i.e. is there a simple ...
In biochemical definitions, "functional" DNA relates to DNA sequences that specify molecular products (e.g. noncoding RNAs) and biochemical activities with mechanistic roles in gene or genome regulation (i.e. DNA sequences that impact cellular level activity such as cell type, condition, and molecular processes).
For enzymes, predictions of specific functions are especially difficult, as they only need a few key residues in their active site, hence very different sequences can have very similar activities. By contrast, even with sequence identity of 70% or greater, 10% of any pair of enzymes have different substrates; and differences in the actual ...
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A genome sequence is the complete list of the nucleotides (A, C, G, and T for DNA genomes) that make up all the chromosomes of an individual or a species. Within a species, the vast majority of nucleotides are identical between individuals, but sequencing multiple individuals is necessary to understand the genetic diversity.
Enjoy a classic game of Hearts and watch out for the Queen of Spades!
Bird flu has been on the rise in Washington state and one sanctuary was hit hard: 20 big cats – more than half of the facility’s population – died over the course of weeks.
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