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Hormone secreting pituitary adenomas cause one of several forms of hyperpituitarism.The specifics depend on the type of hormone. Some tumors secrete more than one hormone, the most common combination [8] being GH and prolactin, which present as gigantism or acromegaly and unexpected lactation (in both men and women).
Hyperpituitarism is a condition due to the primary hypersecretion of pituitary hormones; [3] [medical citation needed] it typically results from a pituitary adenoma.In children with hyperpituitarism, disruption of growth regulation is rare, either because of hormone hypersecretion or because of manifestations caused by local compression of the adenoma.
Prolactin cells are acidophilic by hematoxylin & eosin stains and, If these cells undergo neoplastic transformation, they will give rise to a prolactinoma, a prolactin-secreting pituitary adenoma. [3] Prolactinoma is a tumor of the pituitary gland that is typically non-cancerous. This disorder is more common in females than males.
With pituitary adenomas larger than 1 cm, a baseline pituitary hormonal function test should be done, including measurements of serum levels of TSH, prolactin, IGF-1 (as a test of growth hormone activity), adrenal function (i.e. 24 hour urine cortisol, dexamethasone suppression test), testosterone in men, and estradiol in amenorrheic women. [11]
The neuroendocrine system includes endocrine glands such as the pituitary, the parathyroids and the neuroendocrine adrenals, as well as endocrine islet tissue embedded within glandular tissue such as in the pancreas, and scattered cells in the exocrine parenchyma. The latter is known as the diffuse endocrine system. [2] [3]
While headaches are a symptom common to any tumor within the cranium, vision problems are especially frequent in pituitary adenomas because the pituitary gland rests over the optic chiasm. As the tumor grows, it begins to compress one or both optic nerves, depending on the size and direction of growth. This is an example of mass effect. As such ...
Hyperparathyroidism is present in ≥ 90% of patients. Asymptomatic hypercalcemia is the most common manifestation: about 25% of patients have evidence of nephrolithiasis or nephrocalcinosis. In contrast to sporadic cases of hyperparathyroidism, diffuse hyperplasia or multiple adenomas are more common than solitary adenomas.
The most common cause of hyperprolactinemia is prolactinoma (a type of pituitary adenoma). [3] A blood serum prolactin level of 1000–5000 mIU/L (47–235 ng/mL) may arise from either mechanism, however levels >5000 mIU/L (>235 ng/mL) is likely due to the activity of an adenoma. Prolactin blood levels are typically correlated to the size of ...