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79136 n/a Ensembl ENSG00000255552 n/a UniProt n a n/a RefSeq (mRNA) NM_001003721 NM_024123 n/a RefSeq (protein) n/a n/a Location (UCSC) n/a n/a PubMed search n/a Wikidata View/Edit Human Lymphocyte antigen 6 complex, locus G6E (pseudogene) is a protein that in humans is encoded by the LY6G6E gene. Function LY6G6E belongs to a cluster of leukocyte antigen-6 (LY6) genes located in the major ...
Ly6 proteins are characterized by the LU domain.Typically, they contain one LU domain, but some members of the family have multiple LU domains.The LU domain consists of 60-80 AA and contains 10 cysteines arranged in a specific pattern that allows the creation of 5 disulfide bridges which in turn allow the formation of a three-fingered (3F) structural motif.
Lymphocyte antigen 6E is a protein that in humans is encoded by the LY6E gene. [ 5 ] [ 6 ] [ 7 ] Increased expression of Ly6E is associated with poor survival outcome in multiple malignancies as determined by a survey of more than 130 published clinical studies of gene expression studies on cancer tissue samples and adjacent normal tissues. [ 8 ]
References range may vary with age, sex, race, pregnancy, [10] diet, use of prescribed or herbal drugs and stress. Reference ranges often depend on the analytical method used, for reasons such as inaccuracy , lack of standardisation , lack of certified reference material and differing antibody reactivity . [ 11 ]
Immunosenescence is the gradual deterioration of the immune system, brought on by natural age advancement.A 2020 review concluded that the adaptive immune system is affected more than the innate immune system. [1]
Most often the lymphocyte count is greater than 5000 cells per microliter (μL) of blood but can be much higher. [41] The presence of lymphocytosis in a person who is elderly should raise strong suspicion for CLL, and a confirmatory diagnostic test, in particular flow cytometry should be performed unless clinically unnecessary. [42]
Reactive lymphocyte surrounded by red blood cells. In immunology, reactive lymphocytes, variant lymphocytes, atypical lymphocytes, Downey cells or Türk cells are cytotoxic (CD8 +) lymphocytes that become large as a result of antigen stimulation. Typically, they can be more than 30 μm in diameter with varying size and shape.
The so-called "window" of immunogenicity in each species is broad but too much or too little antigen can induce tolerance, suppression or immune deviation towards cellular immunity rather than a satisfactory humoral response. Optimal and usual protein antigen levels for immunizing specific species have been reported in the following ranges: