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Long-term efficacy remains poorly characterized. Similar recommendations apply to binge eating disorder. [37] SSRIs provide short-term reductions in binge eating behavior, but have not been associated with significant weight loss. [38] Clinical trials have generated mostly negative results for the use of SSRIs in the treatment of anorexia ...
Antidepressants with a lower half-life, such as paroxetine, duloxetine, and venlafaxine, have been implicated in higher incidences of withdrawal symptoms and more severe withdrawal symptoms. [25] With SSRIs, duration of treatment does not appear associated with the severity of withdrawal symptoms. [24]
What are SSRIs and what does SSRI stand for? SSRIs are a group of antidepressants known as selective serotonin reuptake inhibitors that work to prevent the brain from reabsorbing serotonin, a key ...
Serotonin reuptake inhibitors (SSRI) have been associated with a state of restlessness, lability, agitation, and anxiety termed "activation syndrome". In some people, this state change can increase suicidal tendencies, especially in those under age 25 and during the initial weeks of treatment. [ 2 ]
SSRIs are modern antidepressants often used as a first-line treatment for major depressive disorder. Common SSRIs include Prozac (fluoxetine), Zoloft (sertraline) and Lexapro (escitalopram).
Some people may need antidepressants for a relatively short period (like while grieving the loss of a loved one), or they might need medication long-term, if the depression is chronic.
Symptoms typically persist for a longer time frame in patients taking drugs which have a long elimination half-life, active metabolites, or a protracted duration of action. [6] Cases have reported persisting chronic symptoms, [75] and antidepressant discontinuation may contribute to ongoing features. [76]
In general, large-scale studies do tend to show that long-term use of antidepressants is associated with weight gain side effects. However, study data on escitalopram and weight changes is very ...