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Injuries to the base of the skull can damage nerves that emerge directly from the brain (cranial nerves). Cranial nerve damage may result in: Paralysis of facial muscles; Damage to the nerves responsible for eye movements, which can cause double vision; Damage to the nerves that provide sense of smell; Loss of vision; Loss of facial sensation
Surgery may be performed to seal a CSF leak that does not stop, to relieve pressure on a cranial nerve or repair injury to a blood vessel. [1] Prophylactic antibiotics do not provide a clinical benefit in preventing meningitis. [2] [3] A basilar skull fracture occurs in about 12% of people with a severe head injury. [1]
Brain injury (BI) is the destruction or degeneration of brain cells.Brain injuries occur due to a wide range of internal and external factors. In general, brain damage refers to significant, undiscriminating trauma-induced damage.
This type of nerve damage may cause paralysis of the motor, sensory, and autonomic functions, and is mainly seen in crush injury. [2] If the force creating the nerve damage is removed in a timely fashion, the axon may regenerate, leading to recovery. Electrically, the nerve shows rapid and complete degeneration, with loss of voluntary motor units.
Brain injuries that include brain damage can also be brought on by exposure to toxic chemicals, lack of oxygen, tumors, infections, and stroke. [30] Possible causes of widespread brain damage include birth hypoxia, prolonged hypoxia (shortage of oxygen), poisoning by teratogens (including alcohol), infection, and neurological illness.
Traumatic brain injury is defined as damage to the brain resulting from external mechanical force, such as rapid acceleration or deceleration, impact, blast waves, or penetration by a projectile. [10] Brain function is temporarily or permanently impaired and structural damage may or may not be detectable with current technology. [11]
Cerebral contusion (Latin: contusio cerebri), a form of traumatic brain injury, is a bruise of the brain tissue. [2] Like bruises in other tissues, cerebral contusion can be associated with multiple microhemorrhages, small blood vessel leaks into brain tissue. Contusion occurs in 20–30% of severe head injuries. [3]
High levels of intracellular Ca 2+, the major cause of post-injury cell damage, [30] destroy mitochondria, [11] and trigger phospholipases and proteolytic enzymes that damage Na+ channels and degrade or alter the cytoskeleton and the axoplasm. [31] [26] Excess Ca 2+ can also lead to damage to the blood–brain barrier and swelling of the brain ...