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Conjugated estriol, an extract of the urine of pregnant women and sold under the brand names Progynon and Emmenin in the 1930s, was the predecessor of Premarin. [74] Both of these products contained conjugated estrogens similarly to Premarin, but the estrogens were human estrogens as opposed to equine estrogens and the composition differed.
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Atypical (dual estrogen and nitrogen mustard alkylating antineoplastic): Estramustine phosphate sodium (Emcyt) – 140 mg; Oral estradiol valerate (except in combination with dienogest as an oral contraceptive) is not available in the U.S. and is used primarily in Europe. [2]
8,9-Dehydroestradiol, or Δ 8-17β-estradiol, also known as estra-1,3,5(10),8-tetraen-17β-ol-3-one, is a naturally occurring steroidal estrogen found in horses which is closely related to equilin, equilenin, and estradiol, and, as the 3-sulfate ester sodium salt, is a minor constituent of conjugated estrogens (Premarin). [1]
Estradiol 17β-chloral hemiacetal ether O,O-diacetate Estradiol sulfate: Estradiol 3-sulfate – Estrapronicate: Estradiol 3-propionate 17β-nicotinate Orestrate: Estradiol 3-propionate 17β-(1-cyclohexenyl) ether – Polyestradiol phosphate: Estradiol 17β-phosphate polymer Promestriene: Estradiol 3-propyl 17β-methyl diether
Because of the limited research into potency, delivery methods, and conversion of the various estrogens, a valid scientific understanding of compounded estrogen products has not been achieved. [22] Synthetic estradiol, taken orally, decomposes when absorbed in the gastrointestinal tract and delivers bioidentical estradiol to the bloodstream. [23]
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Estradiol, the base estrogen of most estrogen esters. This is a list of estrogen esters , or ester prodrugs of estrogens . It includes esters, as well as ethers , of steroidal estrogens like estradiol , estrone , and estriol and of nonsteroidal estrogens like the stilbestrols diethylstilbestrol and hexestrol .