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The underlying pathophysiology of major depressive disorder has not been clearly defined. Current evidence points to a complex interaction between neurotransmitter availability and receptor regulation and sensitivity underlying the affective symptoms.
The comprehension of the pathophysiology of the major depressive disorder (MDD) is essential to the strengthening of precision psychiatry. In order to determine the relationship between the pathophysiology of the MDD and its clinical progression, ...
Depression is a mood disorder that causes a persistent feeling of sadness and loss of interest. Also called major depressive disorder or clinical depression, it affects how you feel, think and behave and can lead to a variety of emotional and physical problems.
Pathophysiologic mechanisms include: monoamine hypothesis, genetic, environmental, immunologic, endocrine factors and neurogenesis. •. The Hypothalamo-Pituitary-Adrenal axis is the major neurobiological link between these factors and the development of depression.
The goal of this review is to provide an overview of our current understanding of major depression, from pathophysiology to treatment. In spite of decades of research, relatively little is known about its pathogenesis, other than that risk is largely defined by a combination of ill-defined genetic and environmental factors.
A number of factors (biogenic amine deficiency, genetic, environmental, immunologic, endocrine factors and neurogenesis) have been identified as mechanisms which provide unitary explanations for the pathophysiology of depression.
Introduction. Major depressive disorder (MDD), a main cause of disability worldwide, is characterized by physical changes such as tiredness, weight loss, and appetite loss.
We dissected the genetic and clinical heterogeneity, revealing distinct polygenic architectures across subgroups of depression and demonstrating significantly increased absolute risks for ...
Depression is a genetic and phenotypic complex psychiatric disorder with a lifetime prevalence of 15-20% 1-3. It is often recurrent and accompanied by considerable morbidity and co-morbidity, excess mortality, increased risk of suicide and substantial costs worldwide 4-8.
Several biological mechanisms with a possible role in major depressive disorder (MDD)’s pathophysiology have been identified, and it has been hypothesized that these mechanisms may have a role both...
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