Search results
Results from the WOW.Com Content Network
The deductive argument is called an explanation, its premisses are called the explanans (L: explaining) and the conclusion is called the explanandum (L: to be explained). Depending on a number of additional qualifications, an explanation may be ranked on a scale from potential to true. Not all explanations in science are of the D-N type, however.
The prediction is made by "threading" (i.e. placing, aligning) each amino acid in the target sequence to a position in the template structure, and evaluating how well the target fits the template. After the best-fit template is selected, the structural model of the sequence is built based on the alignment with the chosen template.
The hypothetico-deductive model or method is a proposed description of the scientific method.According to it, scientific inquiry proceeds by formulating a hypothesis in a form that can be falsifiable, using a test on observable data where the outcome is not yet known.
An alpha-helix with hydrogen bonds (yellow dots) The α-helix is the most abundant type of secondary structure in proteins. The α-helix has 3.6 amino acids per turn with an H-bond formed between every fourth residue; the average length is 10 amino acids (3 turns) or 10 Å but varies from 5 to 40 (1.5 to 11 turns).
Aristotle's scientific explanation in Physics resembles the DN model, an idealized form of scientific explanation. [7] The framework of Aristotelian physics—Aristotelian metaphysics—reflected the perspective of this principally biologist, who, amid living entities' undeniable purposiveness, formalized vitalism and teleology, an intrinsic morality in nature. [8]
Ab Initio gene prediction is an intrinsic method based on gene content and signal detection. Because of the inherent expense and difficulty in obtaining extrinsic evidence for many genes, it is also necessary to resort to ab initio gene finding, in which the genomic DNA sequence alone is systematically searched for certain tell-tale signs of protein-coding genes.
The GOR method analyzes sequences to predict alpha helix, beta sheet, turn, or random coil secondary structure at each position based on 17-amino-acid sequence windows. The original description of the method included four scoring matrices of size 17×20, where the columns correspond to the log-odds score, which reflects the probability of finding a given amino acid at each position in the 17 ...
A theory or explanation is hard to vary if all details play a functional role, i.e., cannot be varied or removed without changing the predictions of the theory. Easy to vary (i.e., bad) explanations, in contrast, can be varied to be reconciled with new observations because they are barely connected to the details of the phenomenon of question.