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Includes QUEtiapine indications, dosage/administration, pharmacology, mechanism/onset/duration of action, half-life, dosage forms, interactions, warnings, adverse reactions, off-label uses and more.
This activity outlines the indications, mechanism of action, methods of administration, significant adverse effects, contraindications, monitoring, and toxicity of quetiapine, so providers can direct patient therapy successfully in instances where quetiapine provides a benefit to patient care.
This means quetiapine is a dopamine, serotonin, and adrenergic antagonist, and a potent antihistamine with some anticholinergic properties. [76] Quetiapine binds strongly to serotonin receptors; the drug acts as partial agonist at 5-HT 1A receptors. [77]
SEROQUEL is indicated for the acute treatment of manic episodes associated with bipolar I disorder, both as monotherapy and as an adjunct to lithium or divalproex.
Objective: Three placebo-controlled clinical trials have established the efficacy of the atypical antipsychotic quetiapine (Seroquel) in schizophrenia. These trials were designed and powered to detect a treatment difference in the primary endpoint at Week 6.
Mechanism of action. Although the mechanism of action of quetiapine is not fully understood, several proposed mechanisms exist. In schizophrenia, its actions could occur from the antagonism of dopamine type 2 (D2) and serotonin 2A (5HT2A) receptors.
Due to a relatively short half-life of 7 hours, quetipaine should be administered in 2 daily doses. The following initial titration schedule for schizophrenic patients should be adhered to: 1st day 50 mg, 2nd day 100 mg, 3rd day 200 mg, and 4th day 300 mg.
The mechanism of action of SEROQU EL, as with other drugs having efficacy in the treatment of schizophrenia and acute manic episodes associated with bipolar disorder, is unknown.
Quetiapine (Trade name: Seroquel) is an antipsychotic in the atypical antipsychotic class used in the treatment of schizophrenia, bipolar disorder, and major depressive disorder. It is also commonly used off-label for numerous other indications and psychiatric disorders.
At low doses (50 mg per day), quetiapine has well-demonstrated hypnotic and sedative efects attributable to histamine 1-receptor blockade. With midrange doses (300 mg per day), mood efects are secondary to both dopamin-ergic (D2 receptor) and serotonergic (5HT2A receptor) blockade.