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14-3-3 proteins are a family of conserved regulatory molecules that are expressed in all eukaryotic cells. 14-3-3 proteins have the ability to bind a multitude of functionally diverse signaling proteins, including kinases, phosphatases, and transmembrane receptors. More than 200 signaling proteins have been reported as 14-3-3 ligands.
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 is a protein that in humans is encoded by the GNG2 gene. [5] [6] Heterotrimeric G proteins play vital roles in cellular responses to external signals. The specificity of a G protein-receptor interaction is primarily mediated by the gamma subunit.[supplied by OMIM] [6]
14-3-3 protein gamma is a protein that in humans is encoded by the YWHAG gene. [5] [6] This gene product belongs to the 14-3-3 protein family which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the rat ...
14-3-3 protein zeta/delta (14-3-3ζ) is a protein that in humans is encoded by the YWHAZ gene on chromosome 8. [ 5 ] [ 6 ] The protein encoded by this gene is a member of the 14-3-3 protein family and a central hub protein for many signal transduction pathways.
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 is a signalling protein protein that in humans and vertebrates is encoded by the GNGT2 gene. [5] [6] [7] Either GNGT1 or GNGT2 is the gamma subunit of the G βγ part of transducin (written G(T) or G t), a heterotrimeric G-protein naturally expressed in vertebrate retina rod and cone cell of the eye, where it is thought to play ...
The cycle is completed by the hydrolysis of alpha subunit-bound GTP to GDP, resulting in the re-association of the alpha and beta/gamma subunits and their binding to the receptor, which terminates the signal. [3] The length of the G protein signal is controlled by the duration of the GTP-bound alpha subunit, which can be regulated by RGS ...
Gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain, mediates neuronal inhibition by binding to GABA receptors. The type A GABA receptors are pentameric chloride channels assembled from among many genetic variants of GABA(A) subunits. This gene encodes the gamma 2 subunit of GABA(A) receptor.
A number of these enzymes have specificity for phosphoinositides. Of the phosphoinositide-specific phospholipase C enzymes, C-beta is regulated by heterotrimeric G protein-coupled receptors, while the closely related C-gamma-1 (PLCG1; MIM 172420) and C-gamma-2 enzymes are controlled by receptor tyrosine kinases.