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14-3-3 proteins are a family of conserved regulatory molecules that are expressed in all eukaryotic cells. 14-3-3 proteins have the ability to bind a multitude of functionally diverse signaling proteins, including kinases, phosphatases, and transmembrane receptors. More than 200 signaling proteins have been reported as 14-3-3 ligands.
14-3-3 protein gamma is a protein that in humans is encoded by the YWHAG gene. [5] [6] This gene product belongs to the 14-3-3 protein family which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the rat ...
14-3-3ζ is one of 7 members of the 14-3-3 protein family, which is ubiquitously expressed and highly conserved among plants and mammals. [6] [7] [11] [12] This protein family is known for regulating signal transduction pathways primarily through binding phosphoserine proteins, though it can also bind phosphothreonine proteins and unphosphorylated proteins.
22629 Ensembl ENSG00000128245 ENSMUSG00000018965 UniProt Q04917 P68510 RefSeq (mRNA) NM_003405 NM_011738 RefSeq (protein) NP_003396 NP_035868 Location (UCSC) Chr 22: 31.94 – 31.96 Mb Chr 5: 33.18 – 33.19 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse 14-3-3 protein eta also referred to as 14-3-3η is a protein that in humans is encoded by the YWHAH gene. Function This gene ...
7531 22627 Ensembl ENSG00000274474 ENSG00000108953 ENSMUSG00000020849 UniProt P62258 P62259 RefSeq (mRNA) NM_006761 NM_009536 RefSeq (protein) NP_006752 NP_033562 Location (UCSC) Chr 17: 1.34 – 1.4 Mb Chr 11: 75.62 – 75.66 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse 14-3-3 protein epsilon is a protein that in humans is encoded by the YWHAE gene. Function This gene product ...
2810 55948 Ensembl ENSG00000175793 ENSMUSG00000047281 UniProt P31947 O70456 RefSeq (mRNA) NM_006142 NM_018754 RefSeq (protein) NP_006133 NP_061224 Location (UCSC) Chr 1: 26.86 – 26.86 Mb Chr 4: 133.33 – 133.33 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Stratifin (also known as 14-3-3 protein sigma or 14-3-3σ protein) is a protein encoded by the SFN gene in humans. The ...
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102634437 Ensembl ENSG00000134308 n/a UniProt P27348 n/a RefSeq (mRNA) NM_006826 n/a RefSeq (protein) NP_006817 n/a Location (UCSC) Chr 2: 9.58 – 9.63 Mb n/a PubMed search Wikidata View/Edit Human View/Edit Mouse 14-3-3 protein theta is a protein that in humans is encoded by the YWHAQ gene. Function This gene product belongs to the 14-3-3 family of proteins that mediate signal transduction ...