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Ligases are classified as EC 6 in the EC number classification of enzymes. Ligases can be further classified into six subclasses: EC 6.1 includes ligases used to form carbon-oxygen bonds; EC 6.2 includes ligases used to form carbon-sulfur bonds; EC 6.3 includes ligases used to form carbon-nitrogen bonds (including argininosuccinate synthetase)
This list contains a list of EC numbers for the sixth group, EC 6, ligases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology. All official information is tabulated at the website of the committee. [1] The database is developed and maintained by Andrew McDonald ...
The DNA ligase first reacts with ATP or NAD +, forming a ligase-AMP intermediate with the AMP linked to the ε-amino group of lysine in the active site of the ligase via a phosphoramide bond. This adenylyl group is then transferred to the phosphate group at the 5' end of a DNA chain, forming a DNA-adenylate complex. Finally, a phosphodiester ...
Ligases join two molecules with covalent bonds. ... List of EC numbers (EC 6) S. Synthase This page was last edited on 25 March 2013, at 06:51 (UTC). ...
Herbivores and carnivores are examples of organisms that obtain carbon and electrons or hydrogen from living organic matter. Chemoorganotrophs are organisms which use the chemical energy in organic compounds as their energy source and obtain electrons or hydrogen from the organic compounds, including sugars (i.e. glucose ), fats and proteins. [ 2 ]
The Enzyme Commission number (EC number) is a numerical classification scheme for enzymes, based on the chemical reactions they catalyze. [1] As a system of enzyme nomenclature, every EC number is associated with a recommended name for the corresponding enzyme-catalyzed reaction. EC numbers do not specify enzymes but enzyme-catalyzed reactions.
For example, an enzyme that catalyzed this reaction would be an oxidoreductase: A – + B → A + B – In this example, A is the reductant (electron donor) and B is the oxidant (electron acceptor). In biochemical reactions, the redox reactions are sometimes more difficult to see, such as this reaction from glycolysis:
E3 ligases interact with both the target protein and the E2 enzyme, and so impart substrate specificity to the E2. Commonly, E3s polyubiquitinate their substrate with Lys48-linked chains of ubiquitin, targeting the substrate for destruction by the proteasome. However, many other types of linkages are possible and alter a protein's activity ...