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  2. Biochemistry of Alzheimer's disease - Wikipedia

    en.wikipedia.org/wiki/Biochemistry_of_Alzheimer's...

    The biochemistry of Alzheimer's disease, the most common cause of dementia, is not yet very well understood. Alzheimer's disease (AD) has been identified as a proteopathy: a protein misfolding disease due to the accumulation of abnormally folded amyloid beta (Aβ) protein in the brain. [1]

  3. In Alzheimer’s disease, the most common form of dementia, the blood-brain barrier is disrupted. A new study has uncovered unique molecular signatures linked to the disruption of this blood-brain ...

  4. Amyloid beta - Wikipedia

    en.wikipedia.org/wiki/Amyloid_beta

    Brain Aβ is elevated in people with sporadic Alzheimer's disease. Aβ is the main constituent of brain parenchymal and vascular amyloid; it contributes to cerebrovascular lesions and is neurotoxic. [33] [34] [35] It is unresolved how Aβ accumulates in the central nervous system and subsequently initiates the disease of cells. Significant ...

  5. Amyloid plaques - Wikipedia

    en.wikipedia.org/wiki/Amyloid_plaques

    The diagnosis of Alzheimer's disease typically requires a microscopic analysis of plaques and tangles in brain tissue, usually at autopsy. [40] However, Aβ plaques (along with cerebral Aβ-amyloid angiopathy ) can be detected in the brains of living subjects by preparing radiolabeled agents that bind selectively to Aβ deposits in the brain ...

  6. Biomarkers of Alzheimer's disease - Wikipedia

    en.wikipedia.org/wiki/Biomarkers_of_Alzheimer's...

    Recent research has shown that large soluble APP (sAPP) [9] that are present in CSF may serve as a novel potential biomarker of Alzheimer's disease. In an article published in Nature, a group led by Lewczuk performed a test to observe the performance of a soluble form of APP α and β. A significant increase in sAPP α and sAPP β was found in ...

  7. A look at lifestyle changes, diet to address dementia ... - AOL

    www.aol.com/look-lifestyle-changes-diet-address...

    According to the Mayo Clinic some key lifestyle changes to support brain health include the following: Avoid smoking. ... The Alzheimer’s Project, Inc, a not-for-profit group, ...

  8. Alzheimer's-like changes found in COVID patients' brains; flu ...

    www.aol.com/lifestyle/alzheimers-changes-found...

    In Alzheimer's disease, defective ryanodine receptors are linked to accumulation of tau into so-called neurofibrillary tangles. Alzheimer's-like changes found in COVID patients' brains; flu shot ...

  9. Alzheimer's disease - Wikipedia

    en.wikipedia.org/wiki/Alzheimer's_disease

    A normal brain on the left and a late-stage Alzheimer's brain on the right. During the final stage, known as the late-stage or severe stage, there is complete dependence on caregivers. [19] [33] [41] Language is reduced to simple phrases or even single words, eventually leading to complete loss of speech.