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Autoimmune hemolytic anemia (AIHA) is an autoimmune disorder which occurs when antibodies directed against the person's own red blood cells (RBCs) cause them to burst , leading to an insufficient number of oxygen-carrying red blood cells in circulation . The lifetime of the RBCs is reduced from the normal 100–120 days to just a few days in ...
Autoimmune hemolytic anemia: D59.0-D59.1: Autoimmune hemolytic anemia (AIHA) is a type of hemolytic anemia where the body's immune system attacks its own red blood cells (RBCs), leading to their destruction . [28] [29] Types of AIHA include warm autoimmune hemolytic anemia, cold agglutinin disease, and paroxysmal cold hemoglobinuria.
Cold autoimmune hemolytic anemia caused by cold-reacting antibodies. ... B-cell neoplasms - Waldenström macroglobulinemia, lymphoma, chronic lymphoid leukemia, myeloma;
Lymphoma or chronic lymphocytic leukemia associated. [2] Secondary to other malignancies. [2] Associated with SLE or other collagen-vascular disorders. [2] Secondary to viral infection. [2] Cold antibody autoimmune hemolytic anemia [2] Paroxysmal cold hemoglobinuria [2] Drug-induced autoimmune hemolytic anemia [2] Alloimmune hemolytic anemia [1 ...
The most common antibody isotype involved in warm antibody AIHA is IgG, though sometimes IgA is found. The IgG antibodies attach to a red blood cell, leaving their F C portion exposed with maximal reactivity at 37 °C (versus cold antibody induced hemolytic anemia whose antibodies only bind red blood cells at low body temperatures, typically 28–31 °C).
Immune-mediated causes could include transient factors as in Mycoplasma pneumoniae infection (cold agglutinin disease) [14] or permanent factors as in autoimmune diseases like autoimmune hemolytic anemia [15] (itself more common in diseases such as systemic lupus erythematosus, rheumatoid arthritis, Hodgkin's lymphoma, and chronic lymphocytic ...
Autoimmune hemolytic anemia: Anti-red blood cell antibodies Confirmed 1-3 per 100,000 [89] Immune thrombocytopenia: Anti-platelet antibodies Confirmed 3.3 per 100,000 (adults), 50 per 100,000 (children) [90] Thrombotic thrombocytopenic purpura: ADAMTS13 autoantibodies Confirmed 1-2 per million [91] Antiphospholipid syndrome: Antiphospholipid ...
Fostamatinib has been in clinical trials for rheumatoid arthritis, autoimmune thrombocytopenia, autoimmune hemolytic anemia, IgA nephropathy, and lymphoma. [7] [10] The drug is currently being used in a Phase 1 trail to test the safety of the combination of the study drugs fostamatinib and paclitaxel for patients with ovarian cancer. [11]
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