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Clostridioides difficile infection [5] (CDI or C-diff), also known as Clostridium difficile infection, is a symptomatic infection due to the spore-forming bacterium Clostridioides difficile. [6] Symptoms include watery diarrhea , fever, nausea, and abdominal pain . [ 1 ]
Clostridioides difficile (syn. Clostridium difficile) is a bacterium known for causing serious diarrheal infections, and may also cause colon cancer. [4] [5] It is known also as C. difficile, or C. diff (/ s iː d ɪ f /), and is a Gram-positive species of spore-forming bacteria. [6]
The most common organisms are Campylobacter, Clostridioides difficile, Clostridium perfringens, and Salmonella. [86] A large number of toxic plants may also cause symptoms. [87] Some agents are more specific to a certain species. Transmissible gastroenteritis coronavirus (TGEV) occurs in pigs resulting in vomiting, diarrhea, and dehydration. [88]
Symptoms include diarrhea, abdominal pain, gas, bloating, and mucous or blood in stool. It’s often diagnosed via a colonoscopy or other test, and treatments include anti-inflammatory or steroid ...
The toxins are the main virulence factors produced by the gram positive, anaerobic, [2] Clostridioides difficile bacteria. The toxins function by damaging the intestinal mucosa and cause the symptoms of C. difficile infection, including pseudomembranous colitis. TcdA is one of the largest bacterial toxins known.
Clostridioides difficile, also known more commonly as C. diff, accounts for 10 to 20% of antibiotic-associated diarrhea cases, because the antibiotics administered for the treatment of certain disease processes such as inflammatory colitis also inadvertently kill a large portion of the gut flora, the normal flora that is usually present within the bowel.
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