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View/Edit Mouse. Dynamin-like 120 kDa protein, mitochondrial is a protein that in humans is encoded by the OPA1 gene. [5][6] This protein regulates mitochondrial fusion and cristae structure in the inner mitochondrial membrane (IMM) and contributes to ATP synthesis and apoptosis, [7][8][9] and small, round mitochondria. [10]
Mitochondrial fusion. Mitochondria are dynamic organelles with the ability to fuse and divide (fission), forming constantly changing tubular networks in most eukaryotic cells. These mitochondrial dynamics, first observed over a hundred years ago [1] are important for the health of the cell, and defects in dynamics lead to genetic disorders.
Mitofusin-2 (MFN2) is a mitochondrial membrane protein that plays a central role in regulating mitochondrial fusion and cell metabolism. More specifically, MFN2 is a dynamin-like GTPase embedded in the outer mitochondrial membrane (OMM) which in turn affects mitochondrial dynamics, distribution, quality control, and function.
A mitochondrion (pl. mitochondria) is an organelle found in the cells of most eukaryotes, such as animals, plants and fungi. Mitochondria have a double membrane structure and use aerobic respiration to generate adenosine triphosphate (ATP), which is used throughout the cell as a source of chemical energy. [ 2 ]
Dynamin itself is a 96 kDa enzyme, and was first isolated when researchers were attempting to isolate new microtubule -based motors from the bovine brain. Dynamin has been extensively studied in the context of clathrin -coated vesicle budding from the cell membrane. [3][6] Beginning from the N-terminus, Dynamin consists of a GTPase domain ...
The eukaryotic cell cycle consists of four distinct phases: G 1 phase, S phase (synthesis), G 2 phase (collectively known as interphase) and M phase (mitosis and cytokinesis). M phase is itself composed of two tightly coupled processes: mitosis, in which the cell's nucleus divides, and cytokinesis, in which the cell's cytoplasm and cell membrane divides forming two daughter cells.
Fission (biology) Fission, in biology, is the division of a single entity into two or more parts and the regeneration of those parts to separate entities resembling the original. The object experiencing fission is usually a cell, but the term may also refer to how organisms, bodies, populations, or species split into discrete parts. [1][2][3 ...
Protein. The human E3 ubiquitin-protein ligase MARCH5 protein, a member of the transmembrane RING‐finger protein family [8] is 31 kDa in size and composed of 278 amino acids with a N-terminal Zinc-finger domain at amino acid sequence 6-75 and four C-terminal transmembrane spans. [7] The theoretical PI of this protein is 9.00.